Modulating Effects of Cancer-Derived Exosomal miRNAs and Exosomal Processing by Natural Products

Ya Ting Chuang, Jen Yang Tang, Jun Ping Shiau, Ching Yu Yen, Fang Rong Chang, Kun Han Yang, Ming Feng Hou, Ammad Ahmad Farooqi, Hsueh Wei Chang

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Cancer-derived exosomes exhibit sophisticated functions, such as proliferation, apoptosis, migration, resistance, and tumor microenvironment changes. Several clinical drugs modulate these exosome functions, but the impacts of natural products are not well understood. Exosome functions are regulated by exosome processing, such as secretion and assembly. The modulation of these exosome-processing genes can exert the anticancer and precancer effects of cancer-derived exosomes. This review focuses on the cancer-derived exosomal miRNAs that regulate exosome processing, acting on the natural-product-modulating cell functions of cancer cells. However, the role of exosomal processing has been overlooked in several studies of exosomal miRNAs and natural products. In this study, utilizing the bioinformatics database (miRDB), the exosome-processing genes of natural-product-modulated exosomal miRNAs were predicted. Consequently, several natural drugs that modulate exosome processing and exosomal miRNAs and regulate cancer cell functions are described here. This review sheds light on and improves our understanding of the modulating effects of exosomal miRNAs and their potential exosomal processing targets on anticancer treatments based on the use of natural products.

Original languageEnglish
Article number318
Issue number1
Publication statusPublished - Jan 2023


  • cell function
  • exosome
  • miRNA
  • natural product

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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