Abstract
Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction. The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity. The CuS@ENF composite (ENFC) effectively adsorbed H2O2 and near-infrared (NIR) light, enabling it to kill bacteria by photothermal and photocatalytic bactericidal effects. Fu and copper ions were able to release from the ENFC in a pH-dependent manner, and promoted the alkaline phosphatase activity of osteoblast cells and capillary tube formation of endothelial cells. This study provides a new approach to modify CS ENF with antibacterial and osteoblast differentiation activities, which may be available for bone infection prevention and tissue regeneration.
Original language | English |
---|---|
Article number | 119035 |
Journal | Carbohydrate Polymers |
Volume | 281 |
DOIs | |
Publication status | Published - Apr 1 2022 |
Keywords
- Antibacterial
- Bone tissue regeneration
- Chitosan
- CuS nanoparticles
- Nanofibers
- Photocatalytic
- Photothermal
- Wound dressing
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry