Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: A pilot study

Chun Hua Wang, Pai Chien Chou, Wen Ching Joa, Li Fei Chen, Te Fang Sheng, Shu Chuan Ho, Horng Chyuan Lin, Chien Da Huang, Fu Tsai Chung, Kian Fan Chung, Han Pin Kuo

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Background: Moderate-intensity exercise training improves skeletal muscle aerobic capacity and increased oxidative enzyme activity, as well as exercise tolerance in COPD patients. Methods: To investigate whether the home-based exercise training program can reduce inflammatory biomarkers in patients with COPD, twelve patients using mobile phone assistance and 14 with free walk were assessed by incremental shuttle walk test (ISWT), spirometry, strength of limb muscles, and serum C-reactive protein (CRP) and inflammatory cytokines. Results: Patients in the mobile phone group improved their ISWT walking distance, with decrease in serum CRP after 2 months, and sustained at 6 months. Patients in the control group had no improvement. Serum IL-8 in the mobile phone group was significantly reduced at 2, 3 and 6 months after doing home exercise training compared to baseline. IL-6 and TNF-a were significantly elevated at 3 and 6 months in control group, while there were no changes in mobile phone group. The strength of limb muscles was significantly greater compared to baseline at 3 and 6 months in the mobile phone group. Conclusions: A mobile-phone-based system can provide an efficient home endurance exercise training program with improved exercise capacity, strength of limb muscles and a decrease in serum CRP and IL-8 in COPD patients. Decreased systemic inflammation may contribute to these clinical benefits. (Clinical trial registration No.: NCT01631019).

Original languageEnglish
Article number142
JournalBMC Pulmonary Medicine
Issue number1
Publication statusPublished - 2014


  • Biomarker
  • Chronic obstructive pulmonary disease
  • Interleukin-8
  • Mobile phone
  • Pulmonary rehabilitation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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