MMP-1(-1607G) polymorphism as a risk factor for fi brosis after pulmonary tuberculosis in Taiwan

C. H. Wang, H. C. Lin, S. M. Lin, C. D. Huang, C. Y. Liu, K. H. Huang, L. L. Hsieh, K. F. Chung, H. P. Kuo

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25 Citations (Scopus)


SETTING: Several matrix metalloproteinase (MMP) polymorphisms favouring the development of lung fi brosis after pulmonary tuberculosis (TB) have been described. OBJECTIVE: To investigate the association of MMP-1, MMP-9 and MMP-12 polymorphisms with the development of fi brosis in pulmonary TB. DESIGN: We studied 49 normal subjects and 98 TB patients. We analysed the association between MMP polymorphisms and clinical indices of lung fi brosis by serial chest radiography for 1 year after completion of treatment. RESULTS: The frequency of the MMP-1(-1607G) polymorphism was signifi cantly higher in TB patients with moderate to advanced pulmonary fi brosis than in those with minimal to mild fi brosis. Having at least one-1607G MMP-1 polymorphism increased the risk of moderate and advanced fi brosis respectively by 5.04 (95%CI 1.25- 20.30) and 9.87 (95%CI 2.39-40.88) fold. There was no association of MMP-9(-1562T) and MMP-12(Asn357Ser) polymorphisms with lung fi brosis. The production of MMP-1 from monocytes stimulated by interleukin-1â was increased in subjects with the 1G allele genotype compared to the 2G/2G genotype. CONCLUSIONS: Patients with MMP-1(-1607G) polymorphism are more vulnerable to more extensive lung fi brosis 1 year after anti-tuberculosis treatment. This may be related to increased MMP-1 activity, leading to enhanced destruction of the matrix with subsequent fi brosis.

Original languageEnglish
Pages (from-to)627-634
Number of pages8
JournalInternational Journal of Tuberculosis and Lung Disease
Issue number5
Publication statusPublished - May 1 2010
Externally publishedYes


  • Genetic polymorphisms
  • Lung fi brosis
  • Matrix metalloproteinase-1
  • Matrix metalloproteinase-12
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases


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