Mixed meningococcal and tuberculous meningitis

Meningococcal meningitis is one of the most common bacterial infections of the meninges worldwide, and tuberculous infection is the most common cause of chronic meningitis in Taiwan. However, mixed meningococcal and tuberculous meningitis is rare. We describe a 27-year-old woman with a case of culture- proven meningococcal and tuberculous meningitis verified by polymerase chain reaction on a cerebrospinal fluid specimen. The patient was initially treated with intravenous antibiotics including penicillin G and chloramphenicol. Though the patient responded well to therapy initially, her subsequent clinical deterioration was finally controlled by long-term antituberculous medications.