MiRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions

Sheng Da Hsu; Yu Ting Tseng; Sirjana Shrestha; Yu Ling Lin; Anas Khaleel; Chih Hung Chou; Chao Fang Chu; Hsi Yuan Huang; Ching Min Lin; Shu Yi Ho; Ting Yan Jian; Feng Mao Lin; Tzu Hao Chang; Shun Long Weng; Kuang Wen Liao; I. En Liao; Chun Chi Liu; Hsien Da Huang

doi:10.1093/nar/gkt1266

MiRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions

Sheng Da Hsu, Yu Ting Tseng, Sirjana Shrestha, Yu Ling Lin, Anas Khaleel, Chih Hung Chou, Chao Fang Chu, Hsi Yuan Huang, Ching Min Lin, Shu Yi Ho, Ting Yan Jian, Feng Mao Lin, Tzu Hao Chang, Shun Long Weng, Kuang Wen Liao, I. En Liao, Chun Chi Liu, Hsien Da Huang

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Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.

Original language	English
Pages (from-to)	D78-D85
Journal	Nucleic Acids Research
Volume	42
Issue number	D1
DOIs	https://doi.org/10.1093/nar/gkt1266
Publication status	Published - Jan 1 2014

ASJC Scopus subject areas

Genetics

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Hsu, S. D., Tseng, Y. T., Shrestha, S., Lin, Y. L., Khaleel, A., Chou, C. H., Chu, C. F., Huang, H. Y., Lin, C. M., Ho, S. Y., Jian, T. Y., Lin, F. M., Chang, T. H., Weng, S. L., Liao, K. W., Liao, I. E., Liu, C. C., & Huang, H. D. (2014). MiRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions. Nucleic Acids Research, 42(D1), D78-D85. https://doi.org/10.1093/nar/gkt1266

Hsu, SD, Tseng, YT, Shrestha, S, Lin, YL, Khaleel, A, Chou, CH, Chu, CF, Huang, HY, Lin, CM, Ho, SY, Jian, TY, Lin, FM, Chang, TH, Weng, SL, Liao, KW, Liao, IE, Liu, CC & Huang, HD 2014, 'MiRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions', Nucleic Acids Research, vol. 42, no. D1, pp. D78-D85. https://doi.org/10.1093/nar/gkt1266

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abstract = "MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.",

author = "Hsu, {Sheng Da} and Tseng, {Yu Ting} and Sirjana Shrestha and Lin, {Yu Ling} and Anas Khaleel and Chou, {Chih Hung} and Chu, {Chao Fang} and Huang, {Hsi Yuan} and Lin, {Ching Min} and Ho, {Shu Yi} and Jian, {Ting Yan} and Lin, {Feng Mao} and Chang, {Tzu Hao} and Weng, {Shun Long} and Liao, {Kuang Wen} and Liao, {I. En} and Liu, {Chun Chi} and Huang, {Hsien Da}",

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AU - Khaleel, Anas

AU - Chou, Chih Hung

AU - Chu, Chao Fang

AU - Huang, Hsi Yuan

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AU - Jian, Ting Yan

AU - Lin, Feng Mao

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AU - Weng, Shun Long

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AU - Liu, Chun Chi

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N2 - MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.

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MiRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions

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