@article{0b305c9ba6a844989d57d3904af1ebd2,
title = "Minocycline attenuates 5-fluorouracil-induced small intestinal mucositis in mouse model",
abstract = "Minocycline exerts anti-inflammatory and anti-apoptotic effects distinct from its antimicrobial function. In this study we investigated the effect of this drug on chemotherapy-induced gut damage. Body weight loss results, diarrhea scores, and villi measurements showed that minocycline attenuated the severity of intestinal mucositis induced by 5-fluorouracil (5-FU). Minocycline repressed the expression of TNF-α, IL-1β, and iNOS, decreased the apoptotic index, and inhibited poly(ADP-ribose) polymerase-1 (PARP-1) activity in the mouse small intestine. In vitro experiments showed that minocycline suppressed the upregulation of PARP-1 activity in enterocyte IEC-6 cells treated with 5-FU. In addition, minocycline treatment appeared to enhance the antitumor effects of 5-FU in tumor CT-26 xenograft mice. Our results indicate that minocycline protects mice from gut injury induced by 5-FU and enhances the antitumor effects of 5-FU in xenograft mice. These observations suggest that minocycline treatment may benefit patients undergoing standard cancer chemotherapy by alleviating chemical-associated intestinal mucositis. {\textcopyright} 2009 Elsevier Inc. All rights reserved.",
keywords = "5-Fluorouracil, Chemotherapy, Minocycline, Mucositis, fluorouracil, inducible nitric oxide synthase, interleukin 1beta, minocycline, nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1, poly(adenosine diphosphate ribose), tumor necrosis factor alpha, animal cell, animal experiment, animal model, animal tissue, antineoplastic activity, article, body weight, cell proliferation, colon cancer, controlled study, diarrhea, disease severity, drug effect, drug potentiation, enzyme activity, in vitro study, intestine villus, male, mouse, mucosa inflammation, nonhuman, priority journal, protein expression, small intestine disease, small intestine mucositis, treatment response, upregulation, Animals, Anti-Inflammatory Agents, Non-Steroidal, Antimetabolites, Antineoplastic, Apoptosis, Cell Proliferation, Cytokines, Disease Models, Animal, Fluorouracil, Intestine, Small, Male, Mice, Mice, Inbred BALB C, Neoplasms, Nitric Oxide Synthase Type II, Poly(ADP-ribose) Polymerases, Xenograft Model Antitumor Assays, Mus",
author = "Tien-Yu Huang and Heng-Cheng Chu and Yi-Ling Lin and Whae-Hong Ho and Hsien-San Hou and You-Chen Chao and Ching-Len Liao",
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year = "2009",
doi = "10.1016/j.bbrc.2009.09.041",
language = "English",
volume = "389",
pages = "634--639",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Elsevier B.V.",
number = "4",
}
