MicroRNAs regulate several functions of normal tissues and malignancies

Kuo Chang Wen; Pi Ling Sung; Ming Shyen Yen; Chi Mu Chuang; Wen Shiung Liou; Peng Hui Wang

doi:10.1016/j.tjog.2013.10.002

MicroRNAs regulate several functions of normal tissues and malignancies

Kuo Chang Wen, Pi Ling Sung, Ming Shyen Yen, Chi Mu Chuang, Wen Shiung Liou, Peng Hui Wang

Research output: Contribution to journal › Review article › peer-review

24 Citations (Scopus)

Abstract

MicroRNAs (miRNAs, miRs) are a cluster of naturally occurring small non-coding RNA molecules of 19-24 nucleotides in length. miRs control gene expression post-transcriptionally by binding to a specific site at the 3'-UTR of target mRNA, which results in mRNA cleavage and translation repression. Nearly 1000 miRs in the human genome have been identified, and it is believed that these miRs contribute to at least 60% of the human transcriptome. Recent research has shown that miRs are emerging as important regulators of cellular differentiation and dedifferentiation. In addition, dysregulation of miR expression may play a fundamental role in the onset, progression and dissemination of cancers. In this review, we focus on some paradigms of miR involvement in tumorigenesis, such as ovarian cancer, and also discuss the relationship between miRs and cancer stem cells.

Original language	English
Pages (from-to)	465-469
Number of pages	5
Journal	Taiwanese Journal of Obstetrics and Gynecology
Volume	52
Issue number	4
DOIs	https://doi.org/10.1016/j.tjog.2013.10.002
Publication status	Published - Dec 2013
Externally published	Yes

Keywords

Cancer stem cell
MicroRNA
Ovarian cancer

ASJC Scopus subject areas

Obstetrics and Gynaecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tjog.2013.10.002

Cite this

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title = "MicroRNAs regulate several functions of normal tissues and malignancies",

abstract = "MicroRNAs (miRNAs, miRs) are a cluster of naturally occurring small non-coding RNA molecules of 19-24 nucleotides in length. miRs control gene expression post-transcriptionally by binding to a specific site at the 3'-UTR of target mRNA, which results in mRNA cleavage and translation repression. Nearly 1000 miRs in the human genome have been identified, and it is believed that these miRs contribute to at least 60% of the human transcriptome. Recent research has shown that miRs are emerging as important regulators of cellular differentiation and dedifferentiation. In addition, dysregulation of miR expression may play a fundamental role in the onset, progression and dissemination of cancers. In this review, we focus on some paradigms of miR involvement in tumorigenesis, such as ovarian cancer, and also discuss the relationship between miRs and cancer stem cells.",

keywords = "Cancer stem cell, MicroRNA, Ovarian cancer",

author = "Wen, {Kuo Chang} and Sung, {Pi Ling} and Yen, {Ming Shyen} and Chuang, {Chi Mu} and Liou, {Wen Shiung} and Wang, {Peng Hui}",

year = "2013",

month = dec,

doi = "10.1016/j.tjog.2013.10.002",

language = "English",

volume = "52",

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journal = "Taiwanese Journal of Obstetrics and Gynecology",

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publisher = "Elsevier Ltd",

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TY - JOUR

T1 - MicroRNAs regulate several functions of normal tissues and malignancies

AU - Wen, Kuo Chang

AU - Sung, Pi Ling

AU - Yen, Ming Shyen

AU - Chuang, Chi Mu

AU - Liou, Wen Shiung

AU - Wang, Peng Hui

PY - 2013/12

Y1 - 2013/12

N2 - MicroRNAs (miRNAs, miRs) are a cluster of naturally occurring small non-coding RNA molecules of 19-24 nucleotides in length. miRs control gene expression post-transcriptionally by binding to a specific site at the 3'-UTR of target mRNA, which results in mRNA cleavage and translation repression. Nearly 1000 miRs in the human genome have been identified, and it is believed that these miRs contribute to at least 60% of the human transcriptome. Recent research has shown that miRs are emerging as important regulators of cellular differentiation and dedifferentiation. In addition, dysregulation of miR expression may play a fundamental role in the onset, progression and dissemination of cancers. In this review, we focus on some paradigms of miR involvement in tumorigenesis, such as ovarian cancer, and also discuss the relationship between miRs and cancer stem cells.

AB - MicroRNAs (miRNAs, miRs) are a cluster of naturally occurring small non-coding RNA molecules of 19-24 nucleotides in length. miRs control gene expression post-transcriptionally by binding to a specific site at the 3'-UTR of target mRNA, which results in mRNA cleavage and translation repression. Nearly 1000 miRs in the human genome have been identified, and it is believed that these miRs contribute to at least 60% of the human transcriptome. Recent research has shown that miRs are emerging as important regulators of cellular differentiation and dedifferentiation. In addition, dysregulation of miR expression may play a fundamental role in the onset, progression and dissemination of cancers. In this review, we focus on some paradigms of miR involvement in tumorigenesis, such as ovarian cancer, and also discuss the relationship between miRs and cancer stem cells.

KW - Cancer stem cell

KW - MicroRNA

KW - Ovarian cancer

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U2 - 10.1016/j.tjog.2013.10.002

DO - 10.1016/j.tjog.2013.10.002

M3 - Review article

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SN - 1028-4559

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JO - Taiwanese Journal of Obstetrics and Gynecology

JF - Taiwanese Journal of Obstetrics and Gynecology

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ER -

MicroRNAs regulate several functions of normal tissues and malignancies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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