@article{93fb28d74ecb470ca6a89b9945c68be4,
title = "MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of myc expression in prostate cancer cells",
abstract = "Castration-resistant prostate cancer continues to rely on androgen receptor (AR) expression. AR plays a central role in the development of prostate cancer and progression to castration resistance during and after androgen deprivation therapy. Here, we identified miR-let-7c as a key regulator of expression of AR. miR-let-7c suppresses AR expression and activity in human prostate cancer cells by targeting its transcription via c-Myc. Suppression of AR by let-7c leads to decreased cell proliferation of human prostate cancer cells. Down-regulation of Let-7c in prostate cancer specimens is inversely correlated with AR expression, whereas the expression of Lin28 (a repressor of let-7) is correlated positively with AR expression. Our study demonstrates that the miRNA let-7c plays an important role in the regulation of androgen signaling in prostate cancer by down-regulating AR expression. These results suggest that reconstitution of miR-let-7c may aid in targeting enhanced and hypersensitive AR in advanced prostate cancer. {\textcopyright} 2012 by The American Society for Biochemistry and Molecular Biology, Inc.",
keywords = "Androgen deprivation therapy, Androgen receptors, Down-regulation, Human prostate cancer cells, Key regulators, MicroRNAs, Prostate cancer cells, Prostate cancers, Cell proliferation, Cells, Diseases, androgen receptor, microRNA, microRNA let 7c, Myc protein, unclassified drug, article, binding site, cancer cell culture, cell proliferation, cell survival, chromatin immunoprecipitation, controlled study, down regulation, enzyme reconstitution, gene expression regulation, gene overexpression, genetic transcription, human, human cell, plasmid, priority journal, promoter region, prostate cancer, protein analysis, protein binding, signal transduction, upregulation, Cell Line, Tumor, Cell Proliferation, Gene Expression Regulation, Neoplastic, Humans, Male, Prostatic Neoplasms, Proto-Oncogene Proteins c-myc, Receptors, Androgen, RNA, Neoplasm, RNA-Binding Proteins, Signal Transduction",
author = "N. Nadiminty and R. Tummala and W. Lou and Y. Zhu and J. Zhang and X. Chen and {DeVere White}, R.W. and H.-J. Kung and C.P. Evans and A.C. Gao",
note = "引用次數:103 Export Date: 5 March 2018 CODEN: JBCHA 通訊地址: Nadiminty, N.; Department of Urology, University of California Davis Medical Center, Research III, 4645 2nd Ave, Sacramento, CA 95817, United States; 電子郵件: nnadiminty@ucdavis.edu 化學物質/CAS: LIN-28 protein, human; MYC protein, human; MicroRNAs; Proto-Oncogene Proteins c-myc; RNA, Neoplasm; RNA-Binding Proteins; Receptors, Androgen; mirnlet7 microRNA, human 參考文獻: Chen, Y., Sawyers, C.L., Scher, H.I., Targeting the androgen receptor pathway in prostate cancer (2008) Curr. Opin. Pharmacol., 8, pp. 440-448; Lamont, K.R., Tindall, D.J., Androgen regulation of gene expression (2010) Adv. Cancer Res., 107, pp. 137-162; Coppola, V., De Maria, R., Bonci, D., (2010) Endocr. Relat. Cancer, 17, pp. F1-F17; Shi, X.B., Tepper, C.G., DeVere White, R.W., Cancerous miRNAs and their regulation (2008) Cell Cycle, 7, pp. 1529-1538; Gandellini, P., Folini, M., Zaffaroni, N., Towards the definition of prostate cancer-related microRNAs. 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year = "2012",
month = jan,
doi = "10.1074/jbc.M111.278705",
language = "English",
volume = "287",
pages = "1527--1537",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "2",
}
