Abstract
MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators. Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer. In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction.
Original language | English |
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Pages (from-to) | 1144-1148 |
Number of pages | 5 |
Journal | British Journal of Cancer |
Volume | 103 |
Issue number | 8 |
DOIs | |
Publication status | Published - Oct 12 2010 |
Keywords
- lung cancer
- microRNA
- oncogene
- personalised medicine
- risk stratification
- tumour suppressor
ASJC Scopus subject areas
- Oncology
- Cancer Research