MicroRNA in lung cancer

P. Y. Lin; S. L. Yu; P. C. Yang

doi:10.1038/sj.bjc.6605901

MicroRNA in lung cancer

P. Y. Lin, S. L. Yu, P. C. Yang

Research output: Contribution to journal › Short survey › peer-review

216 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators. Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer. In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction.

Original language	English
Pages (from-to)	1144-1148
Number of pages	5
Journal	British Journal of Cancer
Volume	103
Issue number	8
DOIs	https://doi.org/10.1038/sj.bjc.6605901
Publication status	Published - Oct 12 2010

Keywords

lung cancer
microRNA
oncogene
personalised medicine
risk stratification
tumour suppressor

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6605901

Cite this

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AU - Yu, S. L.

AU - Yang, P. C.

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AB - MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators. Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer. In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction.

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KW - microRNA

KW - oncogene

KW - personalised medicine

KW - risk stratification

KW - tumour suppressor

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MicroRNA in lung cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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