MicroRNA expression profiling in PBMCs: A potential diagnostic biomarker of chronic hepatitis C

Chiu Chun Chang; Chun Che Lin; Wan Ling Hsieh; Hsin Wu Lai; Chia Hsun Tsai; Ya Wen Cheng

doi:10.1155/2014/367157

MicroRNA expression profiling in PBMCs: A potential diagnostic biomarker of chronic hepatitis C

Chiu Chun Chang, Chun Che Lin, Wan Ling Hsieh, Hsin Wu Lai, Chia Hsun Tsai, Ya Wen Cheng

Ph.D. Program for Cancer Molecular Biology and Drug Discovery

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs. We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC.

Original language	English
Article number	367157
Journal	Disease Markers
Volume	2014
DOIs	https://doi.org/10.1155/2014/367157
Publication status	Published - 2014

ASJC Scopus subject areas

Biochemistry, medical
Genetics
Molecular Biology
Clinical Biochemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "MicroRNA expression profiling in PBMCs: A potential diagnostic biomarker of chronic hepatitis C",

abstract = "The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs. We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC.",

author = "Chang, {Chiu Chun} and Lin, {Chun Che} and Hsieh, {Wan Ling} and Lai, {Hsin Wu} and Tsai, {Chia Hsun} and Cheng, {Ya Wen}",

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year = "2014",

doi = "10.1155/2014/367157",

language = "English",

volume = "2014",

journal = "Disease Markers",

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TY - JOUR

T1 - MicroRNA expression profiling in PBMCs

T2 - A potential diagnostic biomarker of chronic hepatitis C

AU - Chang, Chiu Chun

AU - Lin, Chun Che

AU - Hsieh, Wan Ling

AU - Lai, Hsin Wu

AU - Tsai, Chia Hsun

AU - Cheng, Ya Wen

PY - 2014

Y1 - 2014

N2 - The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs. We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC.

AB - The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs. We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC.

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MicroRNA expression profiling in PBMCs: A potential diagnostic biomarker of chronic hepatitis C

Abstract

ASJC Scopus subject areas

UN SDGs

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