Microbial transformations of Isocupressic acid

Shwu Jiuan Lin, John P.N. Rosazza

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Microbial transformations of the labdane-diterpene isocupressic acid (1) with different microorganisms yielded several oxygenated metabolites that were isolated and characterized by MS and NMR spectroscopic analyses. Nocardia aurantia (ATCC 12674) catalyzed the cleavage of the 13,14-double bond to yield a new nor-labdane metabolite, 2. Cunninghamella elegans (-) (NRRL 1393) gave 7β-hydroxyisocupressic acid (3) and labda-7,13(E)-diene- 6β,15,17-triol-19-oic acid (4), and Mucor mucedo (ATCC 20094) gave 2α- hydroxyisocupressic acid (5) and labda-8(17),14-diene-2α,13-diol-19-oic acid (6).

Original languageEnglish
Pages (from-to)922-926
Number of pages5
JournalJournal of Natural Products
Issue number7
Publication statusPublished - Jul 1998

ASJC Scopus subject areas

  • Drug Discovery
  • Analytical Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry


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