Abstract
Microbial transformations of the labdane-diterpene isocupressic acid (1) with different microorganisms yielded several oxygenated metabolites that were isolated and characterized by MS and NMR spectroscopic analyses. Nocardia aurantia (ATCC 12674) catalyzed the cleavage of the 13,14-double bond to yield a new nor-labdane metabolite, 2. Cunninghamella elegans (-) (NRRL 1393) gave 7β-hydroxyisocupressic acid (3) and labda-7,13(E)-diene- 6β,15,17-triol-19-oic acid (4), and Mucor mucedo (ATCC 20094) gave 2α- hydroxyisocupressic acid (5) and labda-8(17),14-diene-2α,13-diol-19-oic acid (6).
| Original language | English |
|---|---|
| Pages (from-to) | 922-926 |
| Number of pages | 5 |
| Journal | Journal of Natural Products |
| Volume | 61 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1998 |
ASJC Scopus subject areas
- Drug Discovery
- Analytical Chemistry
- Molecular Medicine
- Complementary and alternative medicine
- Pharmacology
- Pharmaceutical Science
- Organic Chemistry