TY - JOUR
T1 - Microaneurysm number and distribution in the macula of Chinese type 2 diabetics with early diabetic retinopathy
T2 - A population-based study in Kinmen, Taiwan
AU - Chen, Shih Jen
AU - Chou, Pesus
AU - Lee, An Fei
AU - Lee, Fenq Lih
AU - Hsu, Wen-Ming
AU - Liu, Jorn Hon
AU - Tung, Tao Hsin
PY - 2010/3/1
Y1 - 2010/3/1
N2 - To explore the number and distribution of microaneurysms (MA) in the macula of type 2 diabetics in Kinmen, Taiwan and associated risks for early diabetic retinopathy (DR). A baseline mass screening extracts 971 type 2 diabetics between 1991 and 1993 and follow-up eye screening at 1999 was then done. Number of MA was counted and associated systemic factors collected from a centered 45° color fundus photograph of dilated eyes of type 2 diabetics (Topcon-NW5). Thirty-three (6.2%, n = 527) had MA retinopathy. Those with one eye involved (n = 26) had two mean MA; those with bilateral involvement (n = 7) had four mean per eye. Most MA were located temporally (mean MA = 0.79), then superiorly (mean = 0.58), inferiorly (mean = 0.46) and nasal (mean = 0.28). MA occurred at the 6,000-μm outermost ring (mean = 1.51), then the 3,000-μm ring (mean = 0.35), the 1,500-μm ring (mean = 0.26) and center 500 μm circle (mean = 0.01). After adjusting for confounding factors, early DR with MA was associated with longer duration of type 2 diabetes [odds ratios (OR) = 1.10, 95% confidence interval (CI) 1.00-1.21], higher glycosylated hemoglobin (OR = 1.36, 95%CI 1.11-1.66) and wider waist circumference (OR = 1.04, 95%CI 1.01-1.07). Our photograph grading system suggests that MA number and distribution at the macula may reflect severity of early DR and is a valid tool for predicting the progression of DR. Identifying those factors associated with MA only DR is important in developing prevention strategies for this early microvascular complication of type 2 diabetes.
AB - To explore the number and distribution of microaneurysms (MA) in the macula of type 2 diabetics in Kinmen, Taiwan and associated risks for early diabetic retinopathy (DR). A baseline mass screening extracts 971 type 2 diabetics between 1991 and 1993 and follow-up eye screening at 1999 was then done. Number of MA was counted and associated systemic factors collected from a centered 45° color fundus photograph of dilated eyes of type 2 diabetics (Topcon-NW5). Thirty-three (6.2%, n = 527) had MA retinopathy. Those with one eye involved (n = 26) had two mean MA; those with bilateral involvement (n = 7) had four mean per eye. Most MA were located temporally (mean MA = 0.79), then superiorly (mean = 0.58), inferiorly (mean = 0.46) and nasal (mean = 0.28). MA occurred at the 6,000-μm outermost ring (mean = 1.51), then the 3,000-μm ring (mean = 0.35), the 1,500-μm ring (mean = 0.26) and center 500 μm circle (mean = 0.01). After adjusting for confounding factors, early DR with MA was associated with longer duration of type 2 diabetes [odds ratios (OR) = 1.10, 95% confidence interval (CI) 1.00-1.21], higher glycosylated hemoglobin (OR = 1.36, 95%CI 1.11-1.66) and wider waist circumference (OR = 1.04, 95%CI 1.01-1.07). Our photograph grading system suggests that MA number and distribution at the macula may reflect severity of early DR and is a valid tool for predicting the progression of DR. Identifying those factors associated with MA only DR is important in developing prevention strategies for this early microvascular complication of type 2 diabetes.
KW - Diabetic retinopathy
KW - Microaneurysm
KW - Population-based study
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=76449110020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=76449110020&partnerID=8YFLogxK
U2 - 10.1007/s00592-009-0095-6
DO - 10.1007/s00592-009-0095-6
M3 - Article
C2 - 19183838
AN - SCOPUS:76449110020
SN - 0940-5429
VL - 47
SP - 35
EP - 41
JO - Acta Diabetologica
JF - Acta Diabetologica
IS - 1
ER -