Micro diffuser-type movement inversion sorter for high-efficient sperm sorting

Yu Nan Lin; Peng Chun Chen; Ren Guei Wu; Li Chern Pan; Fan Gang Tseng

doi:10.1109/NEMS.2013.6559904

Micro diffuser-type movement inversion sorter for high-efficient sperm sorting

Yu Nan Lin, Peng Chun Chen, Ren Guei Wu, Li Chern Pan, Fan Gang Tseng

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Citations (Scopus)

Abstract

In this study, we propose a microfluidic device with a diffuser type chamber to differentiate the sperm velocity by gradually lowering down the flow speed in diffuser by gradually increasing the width of the channel. When the sperms' moving speed match the flow speed, the sperms tend to have the ability to flow against the stream, thus separating the sperms at different specific positions along the diffuser according to their motility becomes gentle and fast. Most of the motile sperm will stay in the expanding area and the non-motile sperms will drift to outlet. Different from the previous study we proposed in IEEE NEMS, 2012, here we have three improvements: (1) Sperms can be separated in more detailed quality level. (2) Sperm will be more activated by passing through a dumb bell area than by the traditional methods. (3) The space in the device can accumulate large amount of sperms (∼millions).

Original language	English
Title of host publication	8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
Pages	1058-1061
Number of pages	4
DOIs	https://doi.org/10.1109/NEMS.2013.6559904
Publication status	Published - 2013
Externally published	Yes
Event	8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013 - Suzhou, China Duration: Apr 7 2013 → Apr 10 2013

Other

Other	8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
Country/Territory	China
City	Suzhou
Period	4/7/13 → 4/10/13

Keywords

microfluidic-based chip
separation
sperm

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology (miscellaneous)
Biotechnology

Access to Document

10.1109/NEMS.2013.6559904

Cite this

Lin, YN, Chen, PC, Wu, RG, Pan, LC & Tseng, FG 2013, Micro diffuser-type movement inversion sorter for high-efficient sperm sorting. in 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013., 6559904, pp. 1058-1061, 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013, Suzhou, China, 4/7/13. https://doi.org/10.1109/NEMS.2013.6559904

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abstract = "In this study, we propose a microfluidic device with a diffuser type chamber to differentiate the sperm velocity by gradually lowering down the flow speed in diffuser by gradually increasing the width of the channel. When the sperms' moving speed match the flow speed, the sperms tend to have the ability to flow against the stream, thus separating the sperms at different specific positions along the diffuser according to their motility becomes gentle and fast. Most of the motile sperm will stay in the expanding area and the non-motile sperms will drift to outlet. Different from the previous study we proposed in IEEE NEMS, 2012, here we have three improvements: (1) Sperms can be separated in more detailed quality level. (2) Sperm will be more activated by passing through a dumb bell area than by the traditional methods. (3) The space in the device can accumulate large amount of sperms (∼millions).",

keywords = "microfluidic-based chip, separation, sperm",

author = "Lin, {Yu Nan} and Chen, {Peng Chun} and Wu, {Ren Guei} and Pan, {Li Chern} and Tseng, {Fan Gang}",

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AU - Lin, Yu Nan

AU - Chen, Peng Chun

AU - Wu, Ren Guei

AU - Pan, Li Chern

AU - Tseng, Fan Gang

PY - 2013

Y1 - 2013

N2 - In this study, we propose a microfluidic device with a diffuser type chamber to differentiate the sperm velocity by gradually lowering down the flow speed in diffuser by gradually increasing the width of the channel. When the sperms' moving speed match the flow speed, the sperms tend to have the ability to flow against the stream, thus separating the sperms at different specific positions along the diffuser according to their motility becomes gentle and fast. Most of the motile sperm will stay in the expanding area and the non-motile sperms will drift to outlet. Different from the previous study we proposed in IEEE NEMS, 2012, here we have three improvements: (1) Sperms can be separated in more detailed quality level. (2) Sperm will be more activated by passing through a dumb bell area than by the traditional methods. (3) The space in the device can accumulate large amount of sperms (∼millions).

AB - In this study, we propose a microfluidic device with a diffuser type chamber to differentiate the sperm velocity by gradually lowering down the flow speed in diffuser by gradually increasing the width of the channel. When the sperms' moving speed match the flow speed, the sperms tend to have the ability to flow against the stream, thus separating the sperms at different specific positions along the diffuser according to their motility becomes gentle and fast. Most of the motile sperm will stay in the expanding area and the non-motile sperms will drift to outlet. Different from the previous study we proposed in IEEE NEMS, 2012, here we have three improvements: (1) Sperms can be separated in more detailed quality level. (2) Sperm will be more activated by passing through a dumb bell area than by the traditional methods. (3) The space in the device can accumulate large amount of sperms (∼millions).

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Y2 - 7 April 2013 through 10 April 2013

ER -

Micro diffuser-type movement inversion sorter for high-efficient sperm sorting

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Keywords

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