Metoclopramide-induced supersensitivity psychosis

Mong Liang Lu, Jan Jhy Pan, Hui Wen Teng, Kuan Pin Su, Winston W. Shen, Lydia Gonzàlez, Denyse Demers

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


OBJECTIVE: To report 2 cases of metoclopramide-induced supersensitivity psychosis. CASE SUMMARIES: A 74-year-old Taiwanese man was treated with metoclopramide 5 mg 4 times daily for 6 months. A second patient, a 65-year-old Taiwanese man, was treated with metoclopramide 5 mg 4 times daily for 3 months. After discontinuation of metoclopramide, both patients developed hallucinatory experiences and delusions. DISCUSSION: This is the first report of metoclopramide-induced supersensitivity psychosis. Chronic administration of a dopamine antagonist (e.g., metoclopramide) might induce dopamine receptor supersensitivity. It is hypothesized that exacerbation or occurrence of psychotic symptoms following neuroleptic withdrawal results from mesolimbic dopamine supersensitivity. CONCLUSIONS: The complications of long-term metoclopramide therapy should be seriously considered when the treatment regimens are being planned. Clinicians should attempt to treat patients with the lowest effective dosage of medication for the briefest therapeutic period to minimize the risks of adverse reactions.

Original languageEnglish
Pages (from-to)1387-1390
Number of pages4
JournalAnnals of Pharmacotherapy
Issue number9
Publication statusPublished - Sept 2002


  • Metoclopramide
  • Supersensitivity psychosis

ASJC Scopus subject areas

  • Pharmacology (medical)


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