Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression

Ya Hsu Yang; Chih Chiang Chiu; Hao Wei Teng; Chih Pang Chu; Ching Jui Chang; Wei Che Chiu; Chin Hsin Chen; Mong Liang Lu; Shen Ing Liu; Shih Yi Huang; Hsing Cheng Liu; I. Wen Sun

doi:10.1111/appy.12242

Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression

Ya Hsu Yang, Chih Chiang Chiu, Hao Wei Teng, Chih Pang Chu, Ching Jui Chang, Wei Che Chiu, Chin Hsin Chen, Mong Liang Lu, Shen Ing Liu, Shih Yi Huang, Hsing Cheng Liu, I. Wen Sun

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Backgrounds: Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD). Methods: People with LLD were assessed by mini-mental state examination and were examined the distribution of APOE ε4 allele, MTHFR, and MTR polymorphisms. Results: Odds ratio of MTR 2756 AA to MTR 2756 AG and GG genotypes for the risk of cognitive impairment was 5.80 (95% confidence interval=1.18-28.50; P=0.03). Conclusion: People with LLD carrying MTR2756 AA genotype have higher risk of cognitive impairment than those carrying G allele.

Original language	English
Article number	e12242
Journal	Asia-Pacific Psychiatry
Volume	9
Issue number	1
DOIs	https://doi.org/10.1111/appy.12242
Publication status	Published - Mar 1 2017

ASJC Scopus subject areas

Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/appy.12242

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Yang, Y. H., Chiu, C. C., Teng, H. W., Chu, C. P., Chang, C. J., Chiu, W. C., Chen, C. H., Lu, M. L., Liu, S. I., Huang, S. Y., Liu, H. C., & Sun, I. W. (2017). Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression. Asia-Pacific Psychiatry, 9(1), Article e12242. https://doi.org/10.1111/appy.12242

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title = "Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression",

abstract = "Backgrounds: Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD). Methods: People with LLD were assessed by mini-mental state examination and were examined the distribution of APOE ε4 allele, MTHFR, and MTR polymorphisms. Results: Odds ratio of MTR 2756 AA to MTR 2756 AG and GG genotypes for the risk of cognitive impairment was 5.80 (95% confidence interval=1.18-28.50; P=0.03). Conclusion: People with LLD carrying MTR2756 AA genotype have higher risk of cognitive impairment than those carrying G allele.",

author = "Yang, {Ya Hsu} and Chiu, {Chih Chiang} and Teng, {Hao Wei} and Chu, {Chih Pang} and Chang, {Ching Jui} and Chiu, {Wei Che} and Chen, {Chin Hsin} and Lu, {Mong Liang} and Liu, {Shen Ing} and Huang, {Shih Yi} and Liu, {Hsing Cheng} and Sun, {I. Wen}",

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year = "2017",

month = mar,

day = "1",

doi = "10.1111/appy.12242",

language = "English",

volume = "9",

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T1 - Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression

AU - Yang, Ya Hsu

AU - Chiu, Chih Chiang

AU - Teng, Hao Wei

AU - Chu, Chih Pang

AU - Chang, Ching Jui

AU - Chiu, Wei Che

AU - Chen, Chin Hsin

AU - Lu, Mong Liang

AU - Liu, Shen Ing

AU - Huang, Shih Yi

AU - Liu, Hsing Cheng

AU - Sun, I. Wen

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Backgrounds: Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD). Methods: People with LLD were assessed by mini-mental state examination and were examined the distribution of APOE ε4 allele, MTHFR, and MTR polymorphisms. Results: Odds ratio of MTR 2756 AA to MTR 2756 AG and GG genotypes for the risk of cognitive impairment was 5.80 (95% confidence interval=1.18-28.50; P=0.03). Conclusion: People with LLD carrying MTR2756 AA genotype have higher risk of cognitive impairment than those carrying G allele.

AB - Backgrounds: Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD). Methods: People with LLD were assessed by mini-mental state examination and were examined the distribution of APOE ε4 allele, MTHFR, and MTR polymorphisms. Results: Odds ratio of MTR 2756 AA to MTR 2756 AG and GG genotypes for the risk of cognitive impairment was 5.80 (95% confidence interval=1.18-28.50; P=0.03). Conclusion: People with LLD carrying MTR2756 AA genotype have higher risk of cognitive impairment than those carrying G allele.

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Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression

Abstract

ASJC Scopus subject areas

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