Metallic Ir-decorated iridium oxide nanofibers with programmable performance towards non-enzymatic detection of hydrogen peroxide

Ko Chieh Hsueh, Subbiramaniyan Kubendhiran, Tzu Sen Yang, Kuang Chih Tso, Yu Jen Tao, Shih Chin Pan, Han Po Wu, Jun Ohta, Ren Jei Chung, Lu Yin Lin, Po Chun Chen

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Hydrogen peroxide (H2O2) is an essential biomolecule in various fields, including clinical control and environmental protection. This present work reports a design of a non-enzymatic H2O2 electrochemical sensor. The metallic Ir-decorated iridium oxide nanofibers (IrO2@Ir NFs) are prepared using the electrospinning process followed by annealing at different temperatures (500–900 °C). The resultant materials are characterized through field emission scanning electron microscopy, X-ray diffraction analysis, and X-ray absorption spectroscopy. Furthermore, the electrochemical sensing performance of the IrO2@Ir NFs electrode is evaluated by cyclic voltammetry, electrochemical impedance spectroscopy, and chronoamperometric (i-t) techniques. The sensitivity of the IrO2@Ir NFs modified screen-printed electrode (SPCE) is checked to investigate the effect of annealing temperature on the H2O2 sensing. The performance of the nanofibers in the electro-reduction of H2O2 is programmable by controlling the metallic Ir contents. The IrO2@Ir NFs electrode annealed at 600 °C (IrO2@Ir-600 °C NFs) exhibits better electrocatalytic activity towards the electro-reduction of H2O2. Further, the broad linear range (0.1–1000 µM), low detection limit (LOD) of 0.16 µM with a higher sensitivity of 289 μA/cm2·mM is successfully achieved. Additionally, the IrO2@Ir-600 °C NFs modified SPCE has appreciable selectivity in the presence of potentially interfering biological molecules and the practical applicability was demonstrated in MCF-7 human breast cancer cells.

Original languageEnglish
Article number109456
JournalMicrochemical Journal
Volume195
DOIs
Publication statusPublished - Dec 2023

Keywords

  • Electrospinning technology
  • Hydrogen peroxide
  • Iridium oxide
  • Non-enzymatic
  • Screen-printed carbon electrode

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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