Metabolic syndrome and the risk of suicide: A community-based integrated screening samples cohort study

Jung Chen Chang, Amy Ming Fang Yen, Chau Shoun Lee, Sam Li Sheng Chen, Sherry Yueh Hsia Chiu, Jean Ching Yuan Fann, Hsiu Hsi Chen

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


OBJECTIVE: Metabolic syndrome (MetS) is reportedly associated with mental disorders that are known to increase the risk of suicide. However, it is not known whether this association is independent of other risk indicators of suicide. This study therefore investigated whether metabolic abnormalities increase the risk of suicide during a 10-year follow-up period. METHODS: This prospective study enrolled participants from a community-based integrated screening samples cohort in Taiwan. Of the 76,297 people recruited for this study, 12,094 had MetS at baseline. The independent variables were MetS and its components such as high blood pressure and high blood lipid levels. The outcome was death from suicide (n = 146). RESULTS: MetS was associated with an increased risk of suicide risk by 16% per MetS component (95% confidence interval [CI] = 1%-33%), adjusting for demographics, life-style factors, and clinical correlates. Of the five MetS components, elevated blood pressure was independently associated with suicide-related mortality (adjusted hazard ratio [aHR] = 1.49, 95% CI = 1.03-2.15). CONCLUSIONS: This analysis of community-based longitudinal data showed that MetS and its components, particularly elevated blood pressure, correlated positively with suicide risk after controlling other factors. Therefore, public mental health interventions targeting suicide reduction may need to specifically focus on individuals with hypertension and other components of the MetS.

Original languageEnglish
Pages (from-to)807-814
Number of pages8
JournalPsychosomatic Medicine
Issue number9
Publication statusPublished - Nov 2013


  • blood pressure
  • community-based integrated screening samples
  • hypertension
  • metabolic syndrome
  • mood disorders
  • suicide

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology


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