Metabolic communication in the tumour–immune microenvironment

Kung Chi Kao; Stefania Vilbois; Chin Hsien Tsai; Ping Chih Ho

doi:10.1038/s41556-022-01002-x

Metabolic communication in the tumour–immune microenvironment

Kung Chi Kao, Stefania Vilbois, Chin Hsien Tsai, Ping Chih Ho

Research output: Contribution to journal › Review article › peer-review

133 Citations (Scopus)

Abstract

The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating immune cells and impedes durable clinical remission following immunotherapy. Metabolic communication between cancer cells and their neighbouring immune cells could determine the amplitude and type of immune responses, highlighting a potential involvement of metabolic crosstalk in immune surveillance and escape. In this Review, we explore tumour–immune metabolic crosstalk and discuss potential nutrient-limiting strategies that favour anti-tumour immune responses.

Original language	English
Pages (from-to)	1574-1583
Number of pages	10
Journal	Nature Cell Biology
Volume	24
Issue number	11
DOIs	https://doi.org/10.1038/s41556-022-01002-x
Publication status	Published - Nov 2022
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41556-022-01002-x

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AB - The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating immune cells and impedes durable clinical remission following immunotherapy. Metabolic communication between cancer cells and their neighbouring immune cells could determine the amplitude and type of immune responses, highlighting a potential involvement of metabolic crosstalk in immune surveillance and escape. In this Review, we explore tumour–immune metabolic crosstalk and discuss potential nutrient-limiting strategies that favour anti-tumour immune responses.

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Metabolic communication in the tumour–immune microenvironment

Abstract

ASJC Scopus subject areas

UN SDGs

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