Mesoporous silica nanoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: Potential cancer theranostics

Shih Hsun Cheng; Chia Hung Lee; Chung Shi Yang; Fan Gang Tseng; Chung Yuan Mou; Leu Wei Lo

doi:10.1039/b816636f

Mesoporous silica nanoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: Potential cancer theranostics

Shih Hsun Cheng, Chia Hung Lee, Chung Shi Yang, Fan Gang Tseng, Chung Yuan Mou, Leu Wei Lo

Research output: Contribution to journal › Article › peer-review

145 Citations (Scopus)

Abstract

Functionalization of mesoporous silica nanoparticles (MSNs) with Pd-porphyrins for cancer cell photodynamic therapy is reported. The composite platform, MSN-PdTPP, expands the role of Pd-porphyrins from their routine use as phosphorescence probes for oxygen sensing/imaging (diagnostics) to that of novel nano-photosensitizers for cancer cell phototherapy (therapeutics). The utility of MSN-PdTPP in the phototherapeutic treatment of MDA-MB-231 breast cancer cells is also evaluated, suggesting it is a promising cancer theranostic platform.

Original language	English
Pages (from-to)	1252-1257
Number of pages	6
Journal	Journal of Materials Chemistry
Volume	19
Issue number	9
DOIs	https://doi.org/10.1039/b816636f
Publication status	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
Materials Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/b816636f

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abstract = "Functionalization of mesoporous silica nanoparticles (MSNs) with Pd-porphyrins for cancer cell photodynamic therapy is reported. The composite platform, MSN-PdTPP, expands the role of Pd-porphyrins from their routine use as phosphorescence probes for oxygen sensing/imaging (diagnostics) to that of novel nano-photosensitizers for cancer cell phototherapy (therapeutics). The utility of MSN-PdTPP in the phototherapeutic treatment of MDA-MB-231 breast cancer cells is also evaluated, suggesting it is a promising cancer theranostic platform.",

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AU - Cheng, Shih Hsun

AU - Lee, Chia Hung

AU - Yang, Chung Shi

AU - Tseng, Fan Gang

AU - Mou, Chung Yuan

AU - Lo, Leu Wei

PY - 2009

Y1 - 2009

N2 - Functionalization of mesoporous silica nanoparticles (MSNs) with Pd-porphyrins for cancer cell photodynamic therapy is reported. The composite platform, MSN-PdTPP, expands the role of Pd-porphyrins from their routine use as phosphorescence probes for oxygen sensing/imaging (diagnostics) to that of novel nano-photosensitizers for cancer cell phototherapy (therapeutics). The utility of MSN-PdTPP in the phototherapeutic treatment of MDA-MB-231 breast cancer cells is also evaluated, suggesting it is a promising cancer theranostic platform.

AB - Functionalization of mesoporous silica nanoparticles (MSNs) with Pd-porphyrins for cancer cell photodynamic therapy is reported. The composite platform, MSN-PdTPP, expands the role of Pd-porphyrins from their routine use as phosphorescence probes for oxygen sensing/imaging (diagnostics) to that of novel nano-photosensitizers for cancer cell phototherapy (therapeutics). The utility of MSN-PdTPP in the phototherapeutic treatment of MDA-MB-231 breast cancer cells is also evaluated, suggesting it is a promising cancer theranostic platform.

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Mesoporous silica nanoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: Potential cancer theranostics

Abstract

ASJC Scopus subject areas

UN SDGs

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