Mesoporous materials for encapsulating enzymes

Chia Hung Lee, Tien Sung Lin, Chung Yuan Mou

Research output: Contribution to journalReview articlepeer-review

424 Citations (Scopus)


The unique properties of mesoporous silica (MPS) materials were utilized to immobilze enzymes: huge surface area, modifiable surface, and restricted pore nanospaces. The enzyme confinements in the nanochannels of MPS materials generate synergistic effects that enhance enzyme stability, improve product selectivity, and facilitate separation and reuse of enzymes. The physical chemistry of enzyme confinement, methods of immobilization, catalytic activity and advantages of protein confinements are discussed. In the end, we show that immobilized enzymes in the nanospaces of MPS can be applied as viable biocatalysts for chemical and pharmaceutical industries.

Original languageEnglish
Pages (from-to)165-179
Number of pages15
JournalNano Today
Issue number2
Publication statusPublished - Apr 2009
Externally publishedYes


  • Biocatalysis
  • Enzymes
  • Immobilization
  • Mesoporous materials
  • Nanospace

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • General Materials Science
  • Pharmaceutical Science


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