Mesenchymal stem cells promote neutrophil activation by inducing IL-17 production in CD4+ CD45RO+ T cells

Shu Ching Hsu, Li Tzu Wang, Chao Ling Yao, Hsiu Yu Lai, Kuang Yu Chan, Bing Sin Liu, Pele Chong, Oscar Kuang Sheng Lee, Hsin Wei Chen

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Mesenchymal stem cells (MSCs) are multi-potent with numerous mesenchymal-lineage differentiation potential and immunomodulatory capabilities. However, the immunoregulatory properties of MSCs are not clearly defined. The objective of the present study was to elucidate the role(s) of MSCs in IL-17 production and the subsequent effect(s) on neutrophil activation. We have demonstrated that human bone marrow-derived MSCs (BM-MSCs) instruct anti-CD3/anti-CD28 antibody-activated CD4+ CD45RO+ memory T cells, but not other CD4+ subsets or CD8+ T cells, to produce IL-17 after cell-cell contact. After the addition of IL-17, neutrophil phagocytic activity was increased. This is the first report on the ability of BM-MSCs to induce IL-17 production in memory CD4+ T cells that, in turn, promotes enhanced phagocytic activity of neutrophils. These results suggest that MSCs regulate the functional activation of neutrophils via their role in modulating IL-17 from CD4+ CD45RO+ memory T cells.

Original languageEnglish
Pages (from-to)90-95
Number of pages6
Issue number1
Publication statusPublished - Jan 2013
Externally publishedYes


  • IL-17
  • Memory T cells
  • Mesenchymal stem cell
  • Neutrophil
  • Phagocytosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology


Dive into the research topics of 'Mesenchymal stem cells promote neutrophil activation by inducing IL-17 production in CD4+ CD45RO+ T cells'. Together they form a unique fingerprint.

Cite this