(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo

Hsu Fung Lu; Jia You Liu; Shu Ching Hsueh; Yi Yuan Yang; Jai Sing Yang; Tsu Wei Tan; Lai Fong Kok; Chi Cheng Lu; Sheng Huei Lan; Shan Ying Wu; Shiu Shin Liao; Siu Wan Ip; Jing Gung Chung

(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo

Hsu Fung Lu, Jia You Liu, Shu Ching Hsueh, Yi Yuan Yang, Jai Sing Yang, Tsu Wei Tan, Lai Fong Kok, Chi Cheng Lu, Sheng Huei Lan, Shan Ying Wu, Shiu Shin Liao, Siu Wan Ip, Jing Gung Chung

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

(-)-Menthol ([1-α]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.

Original language	English
Pages (from-to)	285-289
Number of pages	5
Journal	In Vivo
Volume	21
Issue number	2
Publication status	Published - 2007

Keywords

(-)-Menthol
Apoptosis
BALB/c mice
Cytotoxicity
WEHI-3 leukemia cells

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
Cancer Research
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo",

abstract = "(-)-Menthol ([1-α]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.",

keywords = "(-)-Menthol, Apoptosis, BALB/c mice, Cytotoxicity, WEHI-3 leukemia cells",

author = "Lu, {Hsu Fung} and Liu, {Jia You} and Hsueh, {Shu Ching} and Yang, {Yi Yuan} and Yang, {Jai Sing} and Tan, {Tsu Wei} and Kok, {Lai Fong} and Lu, {Chi Cheng} and Lan, {Sheng Huei} and Wu, {Shan Ying} and Liao, {Shiu Shin} and Ip, {Siu Wan} and Chung, {Jing Gung}",

year = "2007",

language = "English",

volume = "21",

pages = "285--289",

journal = "In Vivo",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

number = "2",

}

TY - JOUR

T1 - (-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo

AU - Lu, Hsu Fung

AU - Liu, Jia You

AU - Hsueh, Shu Ching

AU - Yang, Yi Yuan

AU - Yang, Jai Sing

AU - Tan, Tsu Wei

AU - Kok, Lai Fong

AU - Lu, Chi Cheng

AU - Lan, Sheng Huei

AU - Wu, Shan Ying

AU - Liao, Shiu Shin

AU - Ip, Siu Wan

AU - Chung, Jing Gung

PY - 2007

Y1 - 2007

N2 - (-)-Menthol ([1-α]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.

AB - (-)-Menthol ([1-α]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.

KW - (-)-Menthol

KW - Apoptosis

KW - BALB/c mice

KW - Cytotoxicity

KW - WEHI-3 leukemia cells

UR - http://www.scopus.com/inward/record.url?scp=34047220360&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34047220360&partnerID=8YFLogxK

M3 - Article

C2 - 17436578

AN - SCOPUS:34047220360

SN - 0258-851X

VL - 21

SP - 285

EP - 289

JO - In Vivo

JF - In Vivo

IS - 2

ER -

(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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