Medullary Vein Blockage Sign Detected by Susceptibility-Weighted Imaging for Diagnosing Metastatic Brain Tumors

Shih-Hung Yang, Chien-Tai Hong, Chia-Yuen Chen, Wei-Yu Chen, Fong Y. Tsai, Wing P. Chan

Research output: Contribution to conferencePaperpeer-review


Purpose: The aim of this study was to identify an anatomical relationship between deep medullary vein and these three
common brain tumors, which may improve preoperative diagnostic accuracy.
Materials and Methods: Patients with SWI studies of the brain and pathology-confirmed PCNSL, high-grade glioma,
or intraaxial metastatic lesions between 2009 and 2015 were reviewed. On SWI, those whose deep medullary veins
could be visualized within 5-mm range of the enhancing tumor were enrolled into the study. A total of 27 patients were
recruited and images were reviewed for signs of medullary vein blockage (MVB). MVB was defined as a deep
medullary vein terminating at the margin of the tumor. The sensitivity, specificity, and diagnostic accuracy of MVB in
differentiating PCNSL, high-grade glioma, and metastasis were analyzed.
Results: A total of 11 PCNSL, 5 high-grade gliomas, and 11 metastatic cases were reviewed. MVB was not identified
in any of imaging studies for PCNSL or high-grade glioma patients. However, MVB was noted in 9 of 11 metastatic
tumors (81.8%). The MVB sign showed a diagnostic specificity and accuracy of 100% and 92.6%, respectively, for
intraaxial metastatic tumors.
Conclusion: The MVB sign on SWI images has a high accuracy and specificity for differentiating metastatic brain
tumors from PCNSL, high-grade gliomas and thus may aid physicians in treatment planning.
Translated title of the contribution磁敏感加權造影偵測之腦髓質靜脈阻斷徵象診斷腦部轉移腫瘤
Original languageEnglish
Publication statusPublished - Mar 2017
EventThe 66th Annual Meeting of RSROC - NTUH International Convention Center, Taipei, Taiwan
Duration: Mar 18 2017Mar 19 2017


ConferenceThe 66th Annual Meeting of RSROC
Internet address


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