Medium-chain triglycerides lower blood lipids and body weight in streptozotocin-induced type 2 diabetes rats

Ming Hua Sung, Fang Hsuean Liao, Yi Wen Chien

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Medium-chain triglycerides (MCTs) are distinguished from other triglycerides in that each fat molecule consists of 6 to 12 carbons in length. MCTs and long-chain triglycerides (LCTs) are absorbed and utilized in different ways. The aim of this study was to assess the effects of replacing soybean oil with MCT oil, in a low-or high-fat diet, on lipid metabolism in rats with streptozotocin-induced type 2 diabetes mellitus (T2DM). There were, thirty-two T2DM Sprague-Dawley rats divided into low-fat-soybean oil (LS), low-fat-MCT oil (LM), high-fat-soybean oil (HS), and high-fat-MCT oil (HM) groups. After 8 weeks, blood sugar, serum lipids, liver lipids, and enzyme activities related to lipid metabolism were measured. Under a high-fat diet condition, replacement of soybean oil with MCT oil lowered serum low-density lipoprotein cholesterol (LDL-C), non-esterified fatty acids, and liver total cholesterol; whilst it increased serum high-density lipoprotein cholesterol (HDL-C) and the HDL-C/LDL-C ratio. A low-fat diet with MCT oil resulted in lower body weight and reproductive white adipose tissues compared to the HS groups, and higher hepatic acyl-CoA oxidase activities (the key enzyme in the peroxisomal beta-oxidation) compared to the LS group in T2DM rats. In conclusion, MCTs showed more protective effects on cardiovascular health in T2DM rats fed a high-fat diet, by improving serum lipid profiles and reducing hepatic total cholesterol.

Original languageEnglish
Article number963
Issue number8
Publication statusPublished - Aug 1 2018


  • Lipid metabolism
  • Long-chain triglyceride
  • Medium-chain triglyceride
  • Type 2 diabetes mellitus
  • Cholesterol, LDL/blood
  • Diabetes Mellitus, Type 2/blood
  • Diabetes Mellitus, Experimental/blood
  • Streptozocin
  • Blood Glucose/metabolism
  • Insulin/blood
  • Male
  • Adipose Tissue, White/metabolism
  • Rats, Sprague-Dawley
  • Soybean Oil/administration & dosage
  • Triglycerides/administration & dosage
  • Animals
  • Adiposity
  • Cholesterol/blood
  • Cholesterol, HDL/blood
  • Weight Loss
  • Diet, High-Fat
  • Liver/metabolism
  • Biomarkers/blood

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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