TY - JOUR
T1 - Medium-chain triglycerides lower blood lipids and body weight in streptozotocin-induced type 2 diabetes rats
AU - Sung, Ming Hua
AU - Liao, Fang Hsuean
AU - Chien, Yi Wen
N1 - Funding Information:
Acknowledgments: This study was supported by a grant from the National Science Council of Taiwan (NSC95-2320-B-038-039). The authors gratefully acknowledge Hsing-Hsien Cheng for assistance with the Stabilwax-DA capillary column and G-3000 chromatograph detection system. The results/data/figures in this manuscript have not been published elsewhere, nor are they under consideration (from all our contributing authors) by another publisher.
Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Medium-chain triglycerides (MCTs) are distinguished from other triglycerides in that each fat molecule consists of 6 to 12 carbons in length. MCTs and long-chain triglycerides (LCTs) are absorbed and utilized in different ways. The aim of this study was to assess the effects of replacing soybean oil with MCT oil, in a low-or high-fat diet, on lipid metabolism in rats with streptozotocin-induced type 2 diabetes mellitus (T2DM). There were, thirty-two T2DM Sprague-Dawley rats divided into low-fat-soybean oil (LS), low-fat-MCT oil (LM), high-fat-soybean oil (HS), and high-fat-MCT oil (HM) groups. After 8 weeks, blood sugar, serum lipids, liver lipids, and enzyme activities related to lipid metabolism were measured. Under a high-fat diet condition, replacement of soybean oil with MCT oil lowered serum low-density lipoprotein cholesterol (LDL-C), non-esterified fatty acids, and liver total cholesterol; whilst it increased serum high-density lipoprotein cholesterol (HDL-C) and the HDL-C/LDL-C ratio. A low-fat diet with MCT oil resulted in lower body weight and reproductive white adipose tissues compared to the HS groups, and higher hepatic acyl-CoA oxidase activities (the key enzyme in the peroxisomal beta-oxidation) compared to the LS group in T2DM rats. In conclusion, MCTs showed more protective effects on cardiovascular health in T2DM rats fed a high-fat diet, by improving serum lipid profiles and reducing hepatic total cholesterol.
AB - Medium-chain triglycerides (MCTs) are distinguished from other triglycerides in that each fat molecule consists of 6 to 12 carbons in length. MCTs and long-chain triglycerides (LCTs) are absorbed and utilized in different ways. The aim of this study was to assess the effects of replacing soybean oil with MCT oil, in a low-or high-fat diet, on lipid metabolism in rats with streptozotocin-induced type 2 diabetes mellitus (T2DM). There were, thirty-two T2DM Sprague-Dawley rats divided into low-fat-soybean oil (LS), low-fat-MCT oil (LM), high-fat-soybean oil (HS), and high-fat-MCT oil (HM) groups. After 8 weeks, blood sugar, serum lipids, liver lipids, and enzyme activities related to lipid metabolism were measured. Under a high-fat diet condition, replacement of soybean oil with MCT oil lowered serum low-density lipoprotein cholesterol (LDL-C), non-esterified fatty acids, and liver total cholesterol; whilst it increased serum high-density lipoprotein cholesterol (HDL-C) and the HDL-C/LDL-C ratio. A low-fat diet with MCT oil resulted in lower body weight and reproductive white adipose tissues compared to the HS groups, and higher hepatic acyl-CoA oxidase activities (the key enzyme in the peroxisomal beta-oxidation) compared to the LS group in T2DM rats. In conclusion, MCTs showed more protective effects on cardiovascular health in T2DM rats fed a high-fat diet, by improving serum lipid profiles and reducing hepatic total cholesterol.
KW - Lipid metabolism
KW - Long-chain triglyceride
KW - Medium-chain triglyceride
KW - Type 2 diabetes mellitus
KW - Cholesterol, LDL/blood
KW - Diabetes Mellitus, Type 2/blood
KW - Diabetes Mellitus, Experimental/blood
KW - Streptozocin
KW - Blood Glucose/metabolism
KW - Insulin/blood
KW - Male
KW - Adipose Tissue, White/metabolism
KW - Rats, Sprague-Dawley
KW - Soybean Oil/administration & dosage
KW - Triglycerides/administration & dosage
KW - Animals
KW - Adiposity
KW - Cholesterol/blood
KW - Cholesterol, HDL/blood
KW - Weight Loss
KW - Diet, High-Fat
KW - Liver/metabolism
KW - Biomarkers/blood
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U2 - 10.3390/nu10080963
DO - 10.3390/nu10080963
M3 - Article
C2 - 30049949
AN - SCOPUS:85050949743
SN - 2072-6643
VL - 10
JO - Nutrients
JF - Nutrients
IS - 8
M1 - 963
ER -