Mechanobiology of MG63 osteoblast-like cells adaptation to static magnetic forces

Shu Li Lin, Wei Jen Chang, Kang Hsuan Chiu, Sung Chih Hsieh, Sheng Yang Lee, Che Tong Lin, Chang Chih Chen, Haw Ming Huang

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


The aim of this study was to explore the biophysical effects of static magnetic field on osteoblastic cells. MG63 cells were exposed to 0.25 and 0.4-T static magnetic fields (SMF). The cell cycle effects were tested by flow cytometry. The differentiation of the cells was assessed by detecting the changes in prostaglandin E2, osteocalcin, and extracellular matrix expression. Membrane fluidity was used to evaluate the alterations in the biophysical properties of cellular membranes after the SMF simulations. Our results show that SMF exposure increases prostaglandin E2 level and extracellular matrix express in MG63 cells. On the other hand, MG63 cells exposed to 0.4-T SMF exhibited a significant decrease in membrane fluidity at 8 h. Based on these findings, it appears reasonable to suggest that SMF affect osteoblastic maturation by increasing membrane rigidity and then inducing differentiation pathway.

Original languageEnglish
Pages (from-to)55-64
Number of pages10
JournalElectromagnetic Biology and Medicine
Issue number1
Publication statusPublished - Mar 2008


  • Differentiation
  • MG63
  • Mechanobiology
  • Membrane fluidity
  • Osteoblast
  • Static magnetic field

ASJC Scopus subject areas

  • Biophysics
  • Medicine (miscellaneous)


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