Mechanical unfolding and refolding of proteins: An off-lattice model study

Feng Yin Li, Jian Min Yuan, Chung Yuan Mou

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Using an off-lattice model, we investigate the response of a protein molecule to external stretching and release. In particular we study the passive force in a protein as a function of the extension of the protein. These force-extension curves exhibit hysteresis loops, whose areas increase with the pulling rate and decrease with thermal noise. Most of these results seem to be appropriately described by a cusp catastrophe.

Original languageEnglish
JournalPhysical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
Issue number2
Publication statusPublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics


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