Mechanical unfolding and refolding of proteins: An off-lattice model study

Feng Yin Li; Jian Min Yuan; Chung Yuan Mou

doi:10.1103/PhysRevE.63.021905

Mechanical unfolding and refolding of proteins: An off-lattice model study

Feng Yin Li, Jian Min Yuan, Chung Yuan Mou

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Using an off-lattice model, we investigate the response of a protein molecule to external stretching and release. In particular we study the passive force in a protein as a function of the extension of the protein. These force-extension curves exhibit hysteresis loops, whose areas increase with the pulling rate and decrease with thermal noise. Most of these results seem to be appropriately described by a cusp catastrophe.

Original language	English
Journal	Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
Volume	63
Issue number	2
DOIs	https://doi.org/10.1103/PhysRevE.63.021905
Publication status	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Statistical and Nonlinear Physics
Statistics and Probability
Condensed Matter Physics

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10.1103/PhysRevE.63.021905

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abstract = "Using an off-lattice model, we investigate the response of a protein molecule to external stretching and release. In particular we study the passive force in a protein as a function of the extension of the protein. These force-extension curves exhibit hysteresis loops, whose areas increase with the pulling rate and decrease with thermal noise. Most of these results seem to be appropriately described by a cusp catastrophe.",

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AB - Using an off-lattice model, we investigate the response of a protein molecule to external stretching and release. In particular we study the passive force in a protein as a function of the extension of the protein. These force-extension curves exhibit hysteresis loops, whose areas increase with the pulling rate and decrease with thermal noise. Most of these results seem to be appropriately described by a cusp catastrophe.

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Mechanical unfolding and refolding of proteins: An off-lattice model study

Abstract

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