Measurement of axonal excitability: Consensus guidelines

Matthew C. Kiernan, Hugh Bostock, Susanna B. Park, Ryuji Kaji, Christian Krarup, Arun V. Krishnan, Satoshi Kuwabara, Cindy Shin Yi Lin, Sonoko Misawa, Mihai Moldovan, Jiaying Sung, Steve Vucic, Brian J. Wainger, Stephen Waxman, David Burke

Research output: Contribution to journalReview articlepeer-review

50 Citations (Scopus)


Measurement of axonal excitability provides an in vivo indication of the properties of the nerve membrane and of the ion channels expressed on these axons. Axonal excitability techniques have been utilised to investigate the pathophysiological mechanisms underlying neurological diseases. This document presents guidelines derived for such studies, based on a consensus of international experts, and highlights the potential difficulties when interpreting abnormalities in diseased axons. The present manuscript provides a state-of-the-art review of the findings of axonal excitability studies and their interpretation, in addition to suggesting guidelines for the optimal performance of excitability studies.

Original languageEnglish
Pages (from-to)308-323
Number of pages16
JournalClinical Neurophysiology
Issue number1
Publication statusPublished - Jan 2020


  • Axon
  • Excitability
  • Guidelines
  • Peripheral nerve
  • Threshold

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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