Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers

Ching Yu Yen; Chung Ho Chen; Chao Hsiang Chang; Hung Fu Tseng; Shyun Yeu Liu; Li Yeh Chuang; Cheng Hao Wen; Hsueh Wei Chang

doi:10.1080/13547500902829375

Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers

Ching Yu Yen, Chung Ho Chen, Chao Hsiang Chang, Hung Fu Tseng, Shyun Yeu Liu, Li Yeh Chuang, Cheng Hao Wen, Hsueh Wei Chang

School of Dentistry

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

The aim of this study was to investigate the mRNA performance of matrix metalloproteinases (MMP) 1, MMP10 and MMP12 as oral cancer markers. With gingiva as the control, the areas under the receiver- operating characteristic curves (AUCs) of the relative gene expressions for MMP1, MMP10 and MMP12 were 0.715, 0.727 and 0.513, respectively. With the margins or neck platysma muscles as controls, the AUCs of MMP1, MMP10 and MMP12 were 0.746 vs 0.626, 0.712 vs 0.683 and 0.697 vs 0.630, respectively. MMP10 displayed the best sensitivity for oral cancer detection with any controls. MMP1 and MMP10 were suitable markers for cancer detection with gingiva and margin as controls. Using neck tissue as the control, only MMP10 was suitable for cancer detection. With margin and neck controls, there were no significant differences for MMP1, MMP10 and MMP12 in different stages, invasion and locations or different habits. Therefore, MMP1 and MMP10 but not MMP12 are potential oral cancer markers.

Original language	English
Pages (from-to)	244-249
Number of pages	6
Journal	Biomarkers
Volume	14
Issue number	4
DOIs	https://doi.org/10.1080/13547500902829375
Publication status	Published - Jun 2009

Keywords

Matrix metalloproteinases
Oral cancer
Receiver-operating characteristic curves
Tumour marker

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis
Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/13547500902829375

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abstract = "The aim of this study was to investigate the mRNA performance of matrix metalloproteinases (MMP) 1, MMP10 and MMP12 as oral cancer markers. With gingiva as the control, the areas under the receiver- operating characteristic curves (AUCs) of the relative gene expressions for MMP1, MMP10 and MMP12 were 0.715, 0.727 and 0.513, respectively. With the margins or neck platysma muscles as controls, the AUCs of MMP1, MMP10 and MMP12 were 0.746 vs 0.626, 0.712 vs 0.683 and 0.697 vs 0.630, respectively. MMP10 displayed the best sensitivity for oral cancer detection with any controls. MMP1 and MMP10 were suitable markers for cancer detection with gingiva and margin as controls. Using neck tissue as the control, only MMP10 was suitable for cancer detection. With margin and neck controls, there were no significant differences for MMP1, MMP10 and MMP12 in different stages, invasion and locations or different habits. Therefore, MMP1 and MMP10 but not MMP12 are potential oral cancer markers.",

keywords = "Matrix metalloproteinases, Oral cancer, Receiver-operating characteristic curves, Tumour marker",

author = "Yen, {Ching Yu} and Chen, {Chung Ho} and Chang, {Chao Hsiang} and Tseng, {Hung Fu} and Liu, {Shyun Yeu} and Chuang, {Li Yeh} and Wen, {Cheng Hao} and Chang, {Hsueh Wei}",

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doi = "10.1080/13547500902829375",

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AU - Yen, Ching Yu

AU - Chen, Chung Ho

AU - Chang, Chao Hsiang

AU - Tseng, Hung Fu

AU - Liu, Shyun Yeu

AU - Chuang, Li Yeh

AU - Wen, Cheng Hao

AU - Chang, Hsueh Wei

PY - 2009/6

Y1 - 2009/6

N2 - The aim of this study was to investigate the mRNA performance of matrix metalloproteinases (MMP) 1, MMP10 and MMP12 as oral cancer markers. With gingiva as the control, the areas under the receiver- operating characteristic curves (AUCs) of the relative gene expressions for MMP1, MMP10 and MMP12 were 0.715, 0.727 and 0.513, respectively. With the margins or neck platysma muscles as controls, the AUCs of MMP1, MMP10 and MMP12 were 0.746 vs 0.626, 0.712 vs 0.683 and 0.697 vs 0.630, respectively. MMP10 displayed the best sensitivity for oral cancer detection with any controls. MMP1 and MMP10 were suitable markers for cancer detection with gingiva and margin as controls. Using neck tissue as the control, only MMP10 was suitable for cancer detection. With margin and neck controls, there were no significant differences for MMP1, MMP10 and MMP12 in different stages, invasion and locations or different habits. Therefore, MMP1 and MMP10 but not MMP12 are potential oral cancer markers.

AB - The aim of this study was to investigate the mRNA performance of matrix metalloproteinases (MMP) 1, MMP10 and MMP12 as oral cancer markers. With gingiva as the control, the areas under the receiver- operating characteristic curves (AUCs) of the relative gene expressions for MMP1, MMP10 and MMP12 were 0.715, 0.727 and 0.513, respectively. With the margins or neck platysma muscles as controls, the AUCs of MMP1, MMP10 and MMP12 were 0.746 vs 0.626, 0.712 vs 0.683 and 0.697 vs 0.630, respectively. MMP10 displayed the best sensitivity for oral cancer detection with any controls. MMP1 and MMP10 were suitable markers for cancer detection with gingiva and margin as controls. Using neck tissue as the control, only MMP10 was suitable for cancer detection. With margin and neck controls, there were no significant differences for MMP1, MMP10 and MMP12 in different stages, invasion and locations or different habits. Therefore, MMP1 and MMP10 but not MMP12 are potential oral cancer markers.

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KW - Oral cancer

KW - Receiver-operating characteristic curves

KW - Tumour marker

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Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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