Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan

Meng Heng Hsieh; Pai Chien Chou; Chun Liang Chou; Shu Chuan Ho; Wen Ching Joa; Li Fei Chen; Te Fang Sheng; Horng Chyuan Lin; Tsai Yu Wang; Po Jui Chang; Chun Hua Wang; Han Pin Kuo

doi:10.1371/journal.pone.0066265

Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan

Meng Heng Hsieh, Pai Chien Chou, Chun Liang Chou, Shu Chuan Ho, Wen Ching Joa, Li Fei Chen, Te Fang Sheng, Horng Chyuan Lin, Tsai Yu Wang, Po Jui Chang, Chun Hua Wang, Han Pin Kuo

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Objectives:Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis.Design:To investigate the association of MMP-1 polymorphisms with disease severity in non-cystic fibrosis (CF) bronchiectasis patients, 51 normal subjects and 113 patients with bronchiectasis were studied. The associations between MMP-1 polymorphisms, lung function, and disease severity evaluated by high resolution computed tomography (HRCT) were analyzed.Results:The frequency of MMP-1(-1607G) allele was significantly higher in patients with bronchiectasis than normal subjects (70.8% vs 45.1%, p

Original language	English
Article number	e66265
Journal	PLoS One
Volume	8
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0066265
Publication status	Published - Jun 11 2013
Externally published	Yes

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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title = "Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan",

abstract = "Objectives:Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis.Design:To investigate the association of MMP-1 polymorphisms with disease severity in non-cystic fibrosis (CF) bronchiectasis patients, 51 normal subjects and 113 patients with bronchiectasis were studied. The associations between MMP-1 polymorphisms, lung function, and disease severity evaluated by high resolution computed tomography (HRCT) were analyzed.Results:The frequency of MMP-1(-1607G) allele was significantly higher in patients with bronchiectasis than normal subjects (70.8% vs 45.1%, p",

author = "Hsieh, {Meng Heng} and Chou, {Pai Chien} and Chou, {Chun Liang} and Ho, {Shu Chuan} and Joa, {Wen Ching} and Chen, {Li Fei} and Sheng, {Te Fang} and Lin, {Horng Chyuan} and Wang, {Tsai Yu} and Chang, {Po Jui} and Wang, {Chun Hua} and Kuo, {Han Pin}",

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doi = "10.1371/journal.pone.0066265",

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T1 - Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan

AU - Hsieh, Meng Heng

AU - Chou, Pai Chien

AU - Chou, Chun Liang

AU - Ho, Shu Chuan

AU - Joa, Wen Ching

AU - Chen, Li Fei

AU - Sheng, Te Fang

AU - Lin, Horng Chyuan

AU - Wang, Tsai Yu

AU - Chang, Po Jui

AU - Wang, Chun Hua

AU - Kuo, Han Pin

PY - 2013/6/11

Y1 - 2013/6/11

N2 - Objectives:Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis.Design:To investigate the association of MMP-1 polymorphisms with disease severity in non-cystic fibrosis (CF) bronchiectasis patients, 51 normal subjects and 113 patients with bronchiectasis were studied. The associations between MMP-1 polymorphisms, lung function, and disease severity evaluated by high resolution computed tomography (HRCT) were analyzed.Results:The frequency of MMP-1(-1607G) allele was significantly higher in patients with bronchiectasis than normal subjects (70.8% vs 45.1%, p

AB - Objectives:Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis.Design:To investigate the association of MMP-1 polymorphisms with disease severity in non-cystic fibrosis (CF) bronchiectasis patients, 51 normal subjects and 113 patients with bronchiectasis were studied. The associations between MMP-1 polymorphisms, lung function, and disease severity evaluated by high resolution computed tomography (HRCT) were analyzed.Results:The frequency of MMP-1(-1607G) allele was significantly higher in patients with bronchiectasis than normal subjects (70.8% vs 45.1%, p

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Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan

Abstract

ASJC Scopus subject areas

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