Mannose-binding lectin gene polymorphism contributes to recurrence of infective exacerbation in patients with COPD

Chii Lan Lin; Leung Kei Siu; Jung Chung Lin; Chien Ying Liu; Chih Feng Chian; Chun Nin Lee; Feng Yee Chang

doi:10.1378/chest.10-0375

Mannose-binding lectin gene polymorphism contributes to recurrence of infective exacerbation in patients with COPD

Chii Lan Lin, Leung Kei Siu, Jung Chung Lin, Chien Ying Liu, Chih Feng Chian, Chun Nin Lee, Feng Yee Chang

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Background: Mannose-binding lectin (MBL) deficiency is associated with susceptibility to respiratory infections. We investigated the impact of MBL2 gene polymorphisms and MBL deficiency on the recurrence of infective exacerbation in patients with COPD. Methods: A prospective study was conducted among 215 patients with COPD and 137 healthy subjects. MBL deficiency was determined by the MBL2 gene polymorphisms and serum levels of MBL. Results: The average frequency of infective exacerbations over 3 years in the 215 patients with COPD was 2.5 ± 1.3 episodes. The COPD group with three or more episodes of infective exacerbation (recurrent exacerbators) included 96 patients, and the remaining 119 patients had two or fewer episodes (less-frequent exacerbators). Among the 96 recurrent exacerbators, 12 (12.50%) had the MBL deficiency genotype compared with 5 (4.20%) among the less-frequent exacerbators (OR, 3.25; 95% CI, 1.01-11.07; P = .0253). In recurrent exacerbators, the frequency of infective exacerbation was significantly higher in patients with MBL-deficient genotypes than in those with non-MBL-deficient genotypes (4.75 ± 1.22 vs 3.52 ± 0.78, respectively; P

Original language	English
Pages (from-to)	43-51
Number of pages	9
Journal	Chest
Volume	139
Issue number	1
DOIs	https://doi.org/10.1378/chest.10-0375
Publication status	Published - Jan 1 2011
Externally published	Yes

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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title = "Mannose-binding lectin gene polymorphism contributes to recurrence of infective exacerbation in patients with COPD",

abstract = "Background: Mannose-binding lectin (MBL) deficiency is associated with susceptibility to respiratory infections. We investigated the impact of MBL2 gene polymorphisms and MBL deficiency on the recurrence of infective exacerbation in patients with COPD. Methods: A prospective study was conducted among 215 patients with COPD and 137 healthy subjects. MBL deficiency was determined by the MBL2 gene polymorphisms and serum levels of MBL. Results: The average frequency of infective exacerbations over 3 years in the 215 patients with COPD was 2.5 ± 1.3 episodes. The COPD group with three or more episodes of infective exacerbation (recurrent exacerbators) included 96 patients, and the remaining 119 patients had two or fewer episodes (less-frequent exacerbators). Among the 96 recurrent exacerbators, 12 (12.50%) had the MBL deficiency genotype compared with 5 (4.20%) among the less-frequent exacerbators (OR, 3.25; 95% CI, 1.01-11.07; P = .0253). In recurrent exacerbators, the frequency of infective exacerbation was significantly higher in patients with MBL-deficient genotypes than in those with non-MBL-deficient genotypes (4.75 ± 1.22 vs 3.52 ± 0.78, respectively; P",

author = "Lin, {Chii Lan} and Siu, {Leung Kei} and Lin, {Jung Chung} and Liu, {Chien Ying} and Chian, {Chih Feng} and Lee, {Chun Nin} and Chang, {Feng Yee}",

note = "Funding Information: Funding/Support: This study was partly supported by the Teh-Tzer Study Group for Human Medical Research Foundation ( A951102 ). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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AU - Lin, Chii Lan

AU - Siu, Leung Kei

AU - Lin, Jung Chung

AU - Liu, Chien Ying

AU - Chian, Chih Feng

AU - Lee, Chun Nin

AU - Chang, Feng Yee

N1 - Funding Information: Funding/Support: This study was partly supported by the Teh-Tzer Study Group for Human Medical Research Foundation ( A951102 ). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background: Mannose-binding lectin (MBL) deficiency is associated with susceptibility to respiratory infections. We investigated the impact of MBL2 gene polymorphisms and MBL deficiency on the recurrence of infective exacerbation in patients with COPD. Methods: A prospective study was conducted among 215 patients with COPD and 137 healthy subjects. MBL deficiency was determined by the MBL2 gene polymorphisms and serum levels of MBL. Results: The average frequency of infective exacerbations over 3 years in the 215 patients with COPD was 2.5 ± 1.3 episodes. The COPD group with three or more episodes of infective exacerbation (recurrent exacerbators) included 96 patients, and the remaining 119 patients had two or fewer episodes (less-frequent exacerbators). Among the 96 recurrent exacerbators, 12 (12.50%) had the MBL deficiency genotype compared with 5 (4.20%) among the less-frequent exacerbators (OR, 3.25; 95% CI, 1.01-11.07; P = .0253). In recurrent exacerbators, the frequency of infective exacerbation was significantly higher in patients with MBL-deficient genotypes than in those with non-MBL-deficient genotypes (4.75 ± 1.22 vs 3.52 ± 0.78, respectively; P

AB - Background: Mannose-binding lectin (MBL) deficiency is associated with susceptibility to respiratory infections. We investigated the impact of MBL2 gene polymorphisms and MBL deficiency on the recurrence of infective exacerbation in patients with COPD. Methods: A prospective study was conducted among 215 patients with COPD and 137 healthy subjects. MBL deficiency was determined by the MBL2 gene polymorphisms and serum levels of MBL. Results: The average frequency of infective exacerbations over 3 years in the 215 patients with COPD was 2.5 ± 1.3 episodes. The COPD group with three or more episodes of infective exacerbation (recurrent exacerbators) included 96 patients, and the remaining 119 patients had two or fewer episodes (less-frequent exacerbators). Among the 96 recurrent exacerbators, 12 (12.50%) had the MBL deficiency genotype compared with 5 (4.20%) among the less-frequent exacerbators (OR, 3.25; 95% CI, 1.01-11.07; P = .0253). In recurrent exacerbators, the frequency of infective exacerbation was significantly higher in patients with MBL-deficient genotypes than in those with non-MBL-deficient genotypes (4.75 ± 1.22 vs 3.52 ± 0.78, respectively; P

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Mannose-binding lectin gene polymorphism contributes to recurrence of infective exacerbation in patients with COPD

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