@article{1b51428c815442bd9b103d9e95217208,
title = "Mangosteen Concentrate Drink Supplementation Promotes Antioxidant Status and Lactate Clearance in Rats after Exercise",
abstract = "High-strength or long-duration exercise can lead to significant fatigue, oxidative stress, and muscle damage. The purpose of this study was to examine the effect of mangosteen concentrate drink (MCD) supplementation on antioxidant capacity and lactate clearance in rats after running exercise. Forty rats were divided into five groups: N, non-treatment; C, control; or supplemented with MCD, including M1, M5, and M10 (0.9, 4.5, and 9 mL/day) for 6 weeks. The rats were subjected to 30 min running and exhaustive-running tests using a treadmill. The blood lactate; triglyceride; cholesterol and glucose levels; hepatic and muscular malonaldehyde (MDA) levels; and antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT), were analyzed. The results of this study demonstrated that MCD supplementation can increase GPx and CAT activities, alleviate oxidative stress in muscle, and increase lactate clearance, and is thereby beneficial to reduced muscle fatigue after exercise.",
keywords = "antioxidant capacity, exercise, lactate clearance, mangosteen, oxidative stress, Oxidative stress, Exercise, Lactate clearance, Mangosteen, Antioxidant capacity",
author = "Chang, {Ching Chien} and Chen, {Chia Wen} and Eddy Owaga and Lee, {Wan Ting} and Liu, {Ting Ni} and Hsieh, {Rong Hong}",
note = "Funding Information: SupSpulpepmleemnteanryta MryaMtearitaelrsi:alTsh: eT hfoellfoowlloinwginagrea arevaaivlaabillaebolenloinneli naet awtwhtwtp.m://dwpwi.cwo.mm/dxpxix.c/so1m, T/2a0b7l2e-S616:43ti/t1le2./5B/1o4d4y7/ws1e,ight (grams) of the rats during treatment period; Table S2. Diet consumptions (grams) of the rats per week during treatment the rats per week during treatment period. period. Author Contributions: C.-C.C. and R.-H.H. conceived the study, participated in its design, and helped to draft Author Contributions: C.-C.C. and R.-H.H. conceived the study, participated in its design, and helped to draft the manCu.-sCc.rCip.ta.nCd.-CC..-CW.,.CC..-wWe.rCe.,i nWv.o-Tlv.eLd., ianndthTe.b-Nio.cLh.ecmarirciaeldaonuatlytshies aannidmdarlaffeteeddinthgeamndaneuxsecrrciipset. eEx.pOe.rhimelepnetd. Cto.-dCr.aCf.tand C.-W.C. were involved in the biochemical analysis and drafted the manuscript. E.O. helped to draft and improve the Funding: This research was funded by the National Science Council, Taiwan (grant number: NSC 102-2320-B-038-032-MY2). Funding: This research was funded by the National Science Council, Taiwan (grant number: NSC 102-2320-B-038-032-Acknowledgments: The authors thank the School of Nutrition and Health Sciences, Taipei Medical University, MY2). Taiwan, for providing the facilities to carry out this study. This study was supported by a grant from the National Acknowledgments: The authors thank the School of Nutrition and Health Sciences, Taipei Medical University, Taiwan, forCporonvfliidcitnsgofthIne tefarceislti:tiTesh etoaucathrroyrsoduetctlahries nstoucdoyn.fTlihctisofstiuntdeyrewsta. s supported by a grant from the National Science Council, Taiwan (Grant number: NSC 102-2320-B-038-032-MY2). References Conflicts of Interest: The authors declare no conflict of interest. 1. Gladden, L.B. Lactate metabolism: A new paradigm for the third millennium. J. Physiol. 2004, 558, 5–30. Referen[ceCrsossRef] [PubMed] 2. Robergs, R.A.; Ghiasvand, F.; Parker, D. Biochemistry of exercise-induced metabolic acidosis. Am. J. Physiol. 1. Gladden, L.B. Lactate metabolism: A new paradigm for the third millennium. J. Physiol. 2004, 558, 5–30. Regul. Integr. Comp. Physiol. 2004, 287, R502–R516. [CrossRef] [PubMed] 2. Robergs, R.A.; Ghiasvand, F.; Parker, D. Biochemistry of exercise-induced metabolic acidosis. Am. J. Physiol. Regul. 3. McKenna, M.C.; Gruetter, R.; Sonnewald, U.; Waagepetersen, H.S.; Schousboe, A. Energy metabolism of the Integr. Comp. Physiol. 2004, 287, R502–R516. brain. In Basic Neurochemistry: Molecular, Cellular, and Medical Aspects; Siegel, G.J., Albers, R.W., Bradey, S.T., 3. McKenna, M.C.; Gruetter, R.; Sonnewald, U.; Waagepetersen, H.S.; Schousboe, A. Energy metabolism of the brain. Price, D.P., Eds.; Elsevier Academic Press: New York, NY, USA, 2006. In Basic Neurochemistry: Molecular, Cellular, and Medical Aspects; Siegel, G.J., Albers, R.W., Bradey, S.T., Price, D.P., 4. Brooks, G.A. Cell-cell and intracellular lactate shuttles. J. Physiol. 2009, 587, 5591–5600. [CrossRef] [PubMed] Eds.; Elsevier Academic Press: New York, NY, USA, 2006. 5. Van Hall, G. Lactate kinetics in human tissues at rest and during exercise. Acta Physiol. 2010, 199, 499–508. 4. Brooks, G.A. Cell-cell and intracellular lactate shuttles. J. Physiol. 2009, 587, 5591–600. [CrossRef] [PubMed] 6. Pervaiz, N.; Hoffman-Goetz, L. Immune cell inflammatory cytokine responses differ between central and systemic compartments in response to acute exercise in mice. Exerc. Immunol. Rev. 2012, 18, 142–157. Funding Information: This research was funded and approved by the National science Council, Taiwan (grant number: NSC 102-2320-B-038-032-MY2). The authors thank the School of Nutrition and health sciences, Taipei Medical University, Taiwan. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2020",
month = may,
day = "17",
doi = "10.3390/nu12051447",
language = "English",
volume = "12",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "5",
}