Managements of locally advanced unresectable thymic epithelial tumors

Chen Sung Lin, Kuang T. Kuo, Wen H. Hsu, Biing Shiun Huang, Yu Chung Wu, Han Shui Hsu, Min Hsiung Huang, Liang Shun Wang

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Background. Surgery is the treatment of choice for thymic epithelial tumors (TET), but the resectability is about 60-70%. For those with locally advanced unresectable TETs (LAU-TETs), some controversies about the prognostic factors and treatment modalities existed. The aims of this study are to elucidate the roles of various therapeutic options and to determine the survival and prognostic factors of LAU-TETs. Methods. Twenty-seven patients diagnosed with LAU-TETs underwent treatment in Taipei Veterans General Hospital between 1979 and 1997. Multiple treatment modalities, including surgical intervention, irradiation and chemotherapy, were advocated for these patients. The clinicopathological factors and the effects of the treatment modalities were evaluated retrospectively. Results. Twenty seven cases of LAU-TETs, included 18 thymomas (12 at stage III and 6 at stage IVa) and 9 thymic carcinomas (4 at stage III and 5 at stage IVa), were enrolled for study. The overall 5-year and 10-year survival rates were 54.6% and 35.1%, respectively. Patients receiving debulking surgery and those with irradiation dosage higher than 4400 cGy had significantly better survivals (P = 0.021 and P = 0.016, respectively). Conclusions. Aggressive debulking surgery and sufficient irradiation dosage provide better survivals for patients with LAU-TETs, especially for those with thymoma.

Original languageEnglish
Pages (from-to)172-178
Number of pages7
JournalJournal of the Chinese Medical Association
Issue number4
Publication statusPublished - Apr 2004
Externally publishedYes


  • Chemotherapy
  • Irradiation
  • Surgery
  • Thymic carcinoma
  • Thymoma

ASJC Scopus subject areas

  • Medicine(all)


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