Magnolol encapsulated by liposome in inhibiting smooth muscle cell proliferation

Calvin Yu Chian Chen; Chieh Hsi Wu

doi:10.1002/jccs.200800076

Magnolol encapsulated by liposome in inhibiting smooth muscle cell proliferation

Calvin Yu Chian Chen, Chieh Hsi Wu

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Magnolol, a pure compound extracted from Magnolia officinalis, encapsulated by liposome was investigated for inhibiting vascular smooth muscle cell (VSMC) proliferation leading to restenosis by Percutaneous Transluminal Coronary Angioplasty (PTCA). 1,2-Diacyl-Sn-glycero-3-phosphocholine (EPC) and 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine (DPPC) liposomes were utilized to encapsulate the magnolol in this study. The inhibitory efficiency of the liposome encapsulated magnolol on cell viability was higher than the pure magnolol. EPC liposome was found to have higher efficiency in inhibiting VSMCs than DPPC. The diameters of EPC and DPPC liposome which encapsulated magnolol became larger than pure EPC and DPPC liposomes. The photos from transmission electron microscopy (TEM) were demonstrated that the EPC and DPPC liposomes could be interfered by magnolol to form a homogeneous liposome. Addition of cholesterol to EPC and DPPC liposome could reduce the liposome diameter.

Original language	English
Pages (from-to)	517-521
Number of pages	5
Journal	Journal of the Chinese Chemical Society
Volume	55
Issue number	3
DOIs	https://doi.org/10.1002/jccs.200800076
Publication status	Published - 2008
Externally published	Yes

Keywords

DPPC
EPC
Liposome
Magnolol
Proliferation
Vascular smooth muscle cell

ASJC Scopus subject areas

General Chemistry

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10.1002/jccs.200800076

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title = "Magnolol encapsulated by liposome in inhibiting smooth muscle cell proliferation",

abstract = "Magnolol, a pure compound extracted from Magnolia officinalis, encapsulated by liposome was investigated for inhibiting vascular smooth muscle cell (VSMC) proliferation leading to restenosis by Percutaneous Transluminal Coronary Angioplasty (PTCA). 1,2-Diacyl-Sn-glycero-3-phosphocholine (EPC) and 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine (DPPC) liposomes were utilized to encapsulate the magnolol in this study. The inhibitory efficiency of the liposome encapsulated magnolol on cell viability was higher than the pure magnolol. EPC liposome was found to have higher efficiency in inhibiting VSMCs than DPPC. The diameters of EPC and DPPC liposome which encapsulated magnolol became larger than pure EPC and DPPC liposomes. The photos from transmission electron microscopy (TEM) were demonstrated that the EPC and DPPC liposomes could be interfered by magnolol to form a homogeneous liposome. Addition of cholesterol to EPC and DPPC liposome could reduce the liposome diameter.",

keywords = "DPPC, EPC, Liposome, Magnolol, Proliferation, Vascular smooth muscle cell",

author = "Chen, {Calvin Yu Chian} and Wu, {Chieh Hsi}",

year = "2008",

doi = "10.1002/jccs.200800076",

language = "English",

volume = "55",

pages = "517--521",

journal = "Journal of the Chinese Chemical Society",

issn = "0009-4536",

publisher = "John Wiley & Sons Inc.",

number = "3",

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T1 - Magnolol encapsulated by liposome in inhibiting smooth muscle cell proliferation

AU - Chen, Calvin Yu Chian

AU - Wu, Chieh Hsi

PY - 2008

Y1 - 2008

N2 - Magnolol, a pure compound extracted from Magnolia officinalis, encapsulated by liposome was investigated for inhibiting vascular smooth muscle cell (VSMC) proliferation leading to restenosis by Percutaneous Transluminal Coronary Angioplasty (PTCA). 1,2-Diacyl-Sn-glycero-3-phosphocholine (EPC) and 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine (DPPC) liposomes were utilized to encapsulate the magnolol in this study. The inhibitory efficiency of the liposome encapsulated magnolol on cell viability was higher than the pure magnolol. EPC liposome was found to have higher efficiency in inhibiting VSMCs than DPPC. The diameters of EPC and DPPC liposome which encapsulated magnolol became larger than pure EPC and DPPC liposomes. The photos from transmission electron microscopy (TEM) were demonstrated that the EPC and DPPC liposomes could be interfered by magnolol to form a homogeneous liposome. Addition of cholesterol to EPC and DPPC liposome could reduce the liposome diameter.

AB - Magnolol, a pure compound extracted from Magnolia officinalis, encapsulated by liposome was investigated for inhibiting vascular smooth muscle cell (VSMC) proliferation leading to restenosis by Percutaneous Transluminal Coronary Angioplasty (PTCA). 1,2-Diacyl-Sn-glycero-3-phosphocholine (EPC) and 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine (DPPC) liposomes were utilized to encapsulate the magnolol in this study. The inhibitory efficiency of the liposome encapsulated magnolol on cell viability was higher than the pure magnolol. EPC liposome was found to have higher efficiency in inhibiting VSMCs than DPPC. The diameters of EPC and DPPC liposome which encapsulated magnolol became larger than pure EPC and DPPC liposomes. The photos from transmission electron microscopy (TEM) were demonstrated that the EPC and DPPC liposomes could be interfered by magnolol to form a homogeneous liposome. Addition of cholesterol to EPC and DPPC liposome could reduce the liposome diameter.

KW - DPPC

KW - EPC

KW - Liposome

KW - Magnolol

KW - Proliferation

KW - Vascular smooth muscle cell

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DO - 10.1002/jccs.200800076

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EP - 521

JO - Journal of the Chinese Chemical Society

JF - Journal of the Chinese Chemical Society

IS - 3

ER -

Magnolol encapsulated by liposome in inhibiting smooth muscle cell proliferation

Abstract

Keywords

ASJC Scopus subject areas

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