Magnetoresistive Biosensors for Direct Detection of Magnetic Nanoparticle Conjugated Biomarkers on a Chip

H. T. Huang; P. Garu; C. H. Li; W. C. Chang; B. W. Chen; S. Y. Sung; C. M. Lee; J. Y. Chen; T. F. Hsieh; W. J. Sheu; H. Ouyang; W. C. Wang; C. R. Chang; C. L. Wang; M. S. Hsu; Z. H. Wei

doi:10.1142/S2010324719400022

Magnetoresistive Biosensors for Direct Detection of Magnetic Nanoparticle Conjugated Biomarkers on a Chip

H. T. Huang, P. Garu, C. H. Li, W. C. Chang, B. W. Chen, S. Y. Sung, C. M. Lee, J. Y. Chen, T. F. Hsieh, W. J. Sheu, H. Ouyang, W. C. Wang, C. R. Chang, C. L. Wang, M. S. Hsu, Z. H. Wei

Research output: Contribution to journal › Review article › peer-review

37 Citations (Scopus)

Abstract

In this review, we introduce various magnetic biosensors that have been developed. We first explain the advantages of magnetic biosensing and their general operating principles as well as the biolabeling technique for magnetic nanoparticles. Next, we focus on magnetoresistive biosensing technologies because magnetoresistive biosensors will be an essential development direction due to the demand for miniaturization and portable lab-on-a-chip devices. The magnetoresistive effects employed in biosensing include anisotropic magnetoresistance, giant magnetoresistance and tunneling magnetoresistance. In addition to magnetoresistive sensors, the advantages and disadvantages of some nonmagnetoresistive magnetic biosensors are discussed and compared. Finally, we introduce research on integrating magnetic biosensors into the microfluidic laboratory-on-a-chip systems and comment on future development trends.

Original language	English
Article number	1940002
Journal	SPIN
Volume	9
Issue number	2
DOIs	https://doi.org/10.1142/S2010324719400022
Publication status	Published - Jun 1 2019

Keywords

magnetic nanoparticles
Magnetoresistive biosensors
microfluidic laboratory-on-chip system

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering

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10.1142/S2010324719400022

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Huang, H. T., Garu, P., Li, C. H., Chang, W. C., Chen, B. W., Sung, S. Y., Lee, C. M., Chen, J. Y., Hsieh, T. F., Sheu, W. J., Ouyang, H., Wang, W. C., Chang, C. R., Wang, C. L., Hsu, M. S., & Wei, Z. H. (2019). Magnetoresistive Biosensors for Direct Detection of Magnetic Nanoparticle Conjugated Biomarkers on a Chip. SPIN, 9(2), Article 1940002. https://doi.org/10.1142/S2010324719400022

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title = "Magnetoresistive Biosensors for Direct Detection of Magnetic Nanoparticle Conjugated Biomarkers on a Chip",

abstract = "In this review, we introduce various magnetic biosensors that have been developed. We first explain the advantages of magnetic biosensing and their general operating principles as well as the biolabeling technique for magnetic nanoparticles. Next, we focus on magnetoresistive biosensing technologies because magnetoresistive biosensors will be an essential development direction due to the demand for miniaturization and portable lab-on-a-chip devices. The magnetoresistive effects employed in biosensing include anisotropic magnetoresistance, giant magnetoresistance and tunneling magnetoresistance. In addition to magnetoresistive sensors, the advantages and disadvantages of some nonmagnetoresistive magnetic biosensors are discussed and compared. Finally, we introduce research on integrating magnetic biosensors into the microfluidic laboratory-on-a-chip systems and comment on future development trends.",

keywords = "magnetic nanoparticles, Magnetoresistive biosensors, microfluidic laboratory-on-chip system, magnetic nanoparticles, Magnetoresistive biosensors, microfluidic laboratory-on-chip system",

author = "Huang, \{H. T.\} and P. Garu and Li, \{C. H.\} and Chang, \{W. C.\} and Chen, \{B. W.\} and Sung, \{S. Y.\} and Lee, \{C. M.\} and Chen, \{J. Y.\} and Hsieh, \{T. F.\} and Sheu, \{W. J.\} and H. Ouyang and Wang, \{W. C.\} and Chang, \{C. R.\} and Wang, \{C. L.\} and Hsu, \{M. S.\} and Wei, \{Z. H.\}",

note = "Publisher Copyright: {\textcopyright} 2019 World Scientific Publishing Company.",

year = "2019",

month = jun,

day = "1",

doi = "10.1142/S2010324719400022",

language = "English",

volume = "9",

journal = "SPIN",

issn = "2010-3247",

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AU - Huang, H. T.

AU - Garu, P.

AU - Li, C. H.

AU - Chang, W. C.

AU - Chen, B. W.

AU - Sung, S. Y.

AU - Lee, C. M.

AU - Chen, J. Y.

AU - Hsieh, T. F.

AU - Sheu, W. J.

AU - Ouyang, H.

AU - Wang, W. C.

AU - Chang, C. R.

AU - Wang, C. L.

AU - Hsu, M. S.

AU - Wei, Z. H.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - In this review, we introduce various magnetic biosensors that have been developed. We first explain the advantages of magnetic biosensing and their general operating principles as well as the biolabeling technique for magnetic nanoparticles. Next, we focus on magnetoresistive biosensing technologies because magnetoresistive biosensors will be an essential development direction due to the demand for miniaturization and portable lab-on-a-chip devices. The magnetoresistive effects employed in biosensing include anisotropic magnetoresistance, giant magnetoresistance and tunneling magnetoresistance. In addition to magnetoresistive sensors, the advantages and disadvantages of some nonmagnetoresistive magnetic biosensors are discussed and compared. Finally, we introduce research on integrating magnetic biosensors into the microfluidic laboratory-on-a-chip systems and comment on future development trends.

AB - In this review, we introduce various magnetic biosensors that have been developed. We first explain the advantages of magnetic biosensing and their general operating principles as well as the biolabeling technique for magnetic nanoparticles. Next, we focus on magnetoresistive biosensing technologies because magnetoresistive biosensors will be an essential development direction due to the demand for miniaturization and portable lab-on-a-chip devices. The magnetoresistive effects employed in biosensing include anisotropic magnetoresistance, giant magnetoresistance and tunneling magnetoresistance. In addition to magnetoresistive sensors, the advantages and disadvantages of some nonmagnetoresistive magnetic biosensors are discussed and compared. Finally, we introduce research on integrating magnetic biosensors into the microfluidic laboratory-on-a-chip systems and comment on future development trends.

KW - magnetic nanoparticles

KW - Magnetoresistive biosensors

KW - microfluidic laboratory-on-chip system

KW - magnetic nanoparticles

KW - Magnetoresistive biosensors

KW - microfluidic laboratory-on-chip system

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Magnetoresistive Biosensors for Direct Detection of Magnetic Nanoparticle Conjugated Biomarkers on a Chip

Abstract

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