Lung cancer model on chip for drug testing

Kuo Wei Chang; Tushar Harishchandra Punde; Gaurav Prashant Pendharkar; Po Chen Shih; Yao Fei Chan; Kang Yun Lee; Ming Yan Chen; Cheng Hsien Liu

doi:10.1109/TRANSDUCERS.2015.7181006

Lung cancer model on chip for drug testing

Kuo Wei Chang, Tushar Harishchandra Punde, Gaurav Prashant Pendharkar, Po Chen Shih, Yao Fei Chan, Kang Yun Lee, Ming Yan Chen, Cheng Hsien Liu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this paper we have simulated an in vitro lung cancer microenvironment by dielectrophoresis (DEP) patterning. Heterogeneous cells were patterned on the glass substrate, above which a microfluidic gradient is integrated to generate different concentration of target therapy drug (Iressa). Taking advantage of DEP pattern and microfluidic gradient, we designed a biochip to mimic the in vivo conditions. The influence of drug treatment for cell patterning is better than the non-patterned case as visualized in cell viability rate by MTT assay.

Original language	English
Title of host publication	2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	646-649
Number of pages	4
ISBN (Print)	9781479989553
DOIs	https://doi.org/10.1109/TRANSDUCERS.2015.7181006
Publication status	Published - Aug 5 2015
Event	18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States Duration: Jun 21 2015 → Jun 25 2015

Other

Other	18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
Country/Territory	United States
City	Anchorage
Period	6/21/15 → 6/25/15

Keywords

Dielectrophoresis
Gradient Microchannel
Lung Cancer Patterned
Target Therapy Drug

ASJC Scopus subject areas

Instrumentation
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/TRANSDUCERS.2015.7181006

Cite this

Chang, K. W., Punde, T. H., Pendharkar, G. P., Shih, P. C., Chan, Y. F., Lee, K. Y., Chen, M. Y., & Liu, C. H. (2015). Lung cancer model on chip for drug testing. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 (pp. 646-649). [7181006] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2015.7181006

Lung cancer model on chip for drug testing. / Chang, Kuo Wei; Punde, Tushar Harishchandra; Pendharkar, Gaurav Prashant et al.
2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 646-649 7181006.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chang, KW, Punde, TH, Pendharkar, GP, Shih, PC, Chan, YF, Lee, KY, Chen, MY & Liu, CH 2015, Lung cancer model on chip for drug testing. in 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015., 7181006, Institute of Electrical and Electronics Engineers Inc., pp. 646-649, 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Anchorage, United States, 6/21/15. https://doi.org/10.1109/TRANSDUCERS.2015.7181006

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abstract = "In this paper we have simulated an in vitro lung cancer microenvironment by dielectrophoresis (DEP) patterning. Heterogeneous cells were patterned on the glass substrate, above which a microfluidic gradient is integrated to generate different concentration of target therapy drug (Iressa). Taking advantage of DEP pattern and microfluidic gradient, we designed a biochip to mimic the in vivo conditions. The influence of drug treatment for cell patterning is better than the non-patterned case as visualized in cell viability rate by MTT assay.",

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author = "Chang, {Kuo Wei} and Punde, {Tushar Harishchandra} and Pendharkar, {Gaurav Prashant} and Shih, {Po Chen} and Chan, {Yao Fei} and Lee, {Kang Yun} and Chen, {Ming Yan} and Liu, {Cheng Hsien}",

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AU - Chang, Kuo Wei

AU - Punde, Tushar Harishchandra

AU - Pendharkar, Gaurav Prashant

AU - Shih, Po Chen

AU - Chan, Yao Fei

AU - Lee, Kang Yun

AU - Chen, Ming Yan

AU - Liu, Cheng Hsien

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N2 - In this paper we have simulated an in vitro lung cancer microenvironment by dielectrophoresis (DEP) patterning. Heterogeneous cells were patterned on the glass substrate, above which a microfluidic gradient is integrated to generate different concentration of target therapy drug (Iressa). Taking advantage of DEP pattern and microfluidic gradient, we designed a biochip to mimic the in vivo conditions. The influence of drug treatment for cell patterning is better than the non-patterned case as visualized in cell viability rate by MTT assay.

AB - In this paper we have simulated an in vitro lung cancer microenvironment by dielectrophoresis (DEP) patterning. Heterogeneous cells were patterned on the glass substrate, above which a microfluidic gradient is integrated to generate different concentration of target therapy drug (Iressa). Taking advantage of DEP pattern and microfluidic gradient, we designed a biochip to mimic the in vivo conditions. The influence of drug treatment for cell patterning is better than the non-patterned case as visualized in cell viability rate by MTT assay.

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KW - Gradient Microchannel

KW - Lung Cancer Patterned

KW - Target Therapy Drug

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BT - 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015

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Y2 - 21 June 2015 through 25 June 2015

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Lung cancer model on chip for drug testing

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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