Abstract
In this paper we have simulated an in vitro lung cancer microenvironment by dielectrophoresis (DEP) patterning. Heterogeneous cells were patterned on the glass substrate, above which a microfluidic gradient is integrated to generate different concentration of target therapy drug (Iressa). Taking advantage of DEP pattern and microfluidic gradient, we designed a biochip to mimic the in vivo conditions. The influence of drug treatment for cell patterning is better than the non-patterned case as visualized in cell viability rate by MTT assay.
Original language | English |
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Title of host publication | 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 |
Publisher | Institute of Electrical and Electronics Engineers Inc. |
Pages | 646-649 |
Number of pages | 4 |
ISBN (Print) | 9781479989553 |
DOIs | |
Publication status | Published - Aug 5 2015 |
Event | 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States Duration: Jun 21 2015 → Jun 25 2015 |
Other
Other | 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 |
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Country/Territory | United States |
City | Anchorage |
Period | 6/21/15 → 6/25/15 |
Keywords
- Dielectrophoresis
- Gradient Microchannel
- Lung Cancer Patterned
- Target Therapy Drug
ASJC Scopus subject areas
- Instrumentation
- Electrical and Electronic Engineering