Loss of epithelial membrane protein-2 expression confers an independent prognosticator in gallbladder carcinoma

Chien Feng Li; Li Tzong Chen; Ching Yih Lin; Yu Hui Wang; Hsuan Ying Huang; Chung Hsi Hsing; Chia Jung Tsai; Yow Ling Shiue

doi:10.1016/j.gmbhs.2013.04.004

Loss of epithelial membrane protein-2 expression confers an independent prognosticator in gallbladder carcinoma

Chien Feng Li, Li Tzong Chen, Ching Yih Lin, Yu Hui Wang, Hsuan Ying Huang, Chung Hsi Hsing, Chia Jung Tsai, Yow Ling Shiue

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The objective of this study was to evaluate the expression of epithelial membrane protein-2 (EMP2) and its clinicopathological associations in patients with gallbladder carcinoma (GBC). A retrospective population-based cohort study was performed based on a biobank from 1986 to 2005. Biopsies of 164 GBC patients without initial distant metastasis were collected during surgical intervention. Immunoexpressions of EMP2 and Ki-67 were analyzed and the outcomes were correlated with clinicopathological features and patient survival. Results indicated that loss of EMP2 expression (50%) was correlated with female patients ( p=0.037), advanced primary tumor ( p

Original language	English
Pages (from-to)	31-38
Number of pages	8
Journal	Biomarkers and Genomic Medicine
Volume	5
Issue number	1-2
DOIs	https://doi.org/10.1016/j.gmbhs.2013.04.004
Publication status	Published - 2013
Externally published	Yes

Keywords

Epithelial membrane protein-2
Gallbladder carcinoma
Survival

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Biomedical Engineering
Medicine(all)
Drug Discovery

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10.1016/j.gmbhs.2013.04.004

Cite this

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title = "Loss of epithelial membrane protein-2 expression confers an independent prognosticator in gallbladder carcinoma",

abstract = "The objective of this study was to evaluate the expression of epithelial membrane protein-2 (EMP2) and its clinicopathological associations in patients with gallbladder carcinoma (GBC). A retrospective population-based cohort study was performed based on a biobank from 1986 to 2005. Biopsies of 164 GBC patients without initial distant metastasis were collected during surgical intervention. Immunoexpressions of EMP2 and Ki-67 were analyzed and the outcomes were correlated with clinicopathological features and patient survival. Results indicated that loss of EMP2 expression (50%) was correlated with female patients ( p=0.037), advanced primary tumor ( p",

keywords = "Epithelial membrane protein-2, Gallbladder carcinoma, Survival",

author = "Li, {Chien Feng} and Chen, {Li Tzong} and Lin, {Ching Yih} and Wang, {Yu Hui} and Huang, {Hsuan Ying} and Hsing, {Chung Hsi} and Tsai, {Chia Jung} and Shiue, {Yow Ling}",

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doi = "10.1016/j.gmbhs.2013.04.004",

language = "English",

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T1 - Loss of epithelial membrane protein-2 expression confers an independent prognosticator in gallbladder carcinoma

AU - Li, Chien Feng

AU - Chen, Li Tzong

AU - Lin, Ching Yih

AU - Wang, Yu Hui

AU - Huang, Hsuan Ying

AU - Hsing, Chung Hsi

AU - Tsai, Chia Jung

AU - Shiue, Yow Ling

PY - 2013

Y1 - 2013

N2 - The objective of this study was to evaluate the expression of epithelial membrane protein-2 (EMP2) and its clinicopathological associations in patients with gallbladder carcinoma (GBC). A retrospective population-based cohort study was performed based on a biobank from 1986 to 2005. Biopsies of 164 GBC patients without initial distant metastasis were collected during surgical intervention. Immunoexpressions of EMP2 and Ki-67 were analyzed and the outcomes were correlated with clinicopathological features and patient survival. Results indicated that loss of EMP2 expression (50%) was correlated with female patients ( p=0.037), advanced primary tumor ( p

AB - The objective of this study was to evaluate the expression of epithelial membrane protein-2 (EMP2) and its clinicopathological associations in patients with gallbladder carcinoma (GBC). A retrospective population-based cohort study was performed based on a biobank from 1986 to 2005. Biopsies of 164 GBC patients without initial distant metastasis were collected during surgical intervention. Immunoexpressions of EMP2 and Ki-67 were analyzed and the outcomes were correlated with clinicopathological features and patient survival. Results indicated that loss of EMP2 expression (50%) was correlated with female patients ( p=0.037), advanced primary tumor ( p

KW - Epithelial membrane protein-2

KW - Gallbladder carcinoma

KW - Survival

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Loss of epithelial membrane protein-2 expression confers an independent prognosticator in gallbladder carcinoma

Abstract

Keywords

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