Long-term Nucleos(t)ides Analogues for Chronic Hepatitis B Improve Liver and Spleen Size: A Noninvasive Sonographic Study

Ruei Hsin Chang, Tsolmon Nyamsuren, Sarvesh Gyawali, Szu Chieh Fu, Yi Wen Huang, Rui Ting Hu, Sien Sing Yang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background Histological improvement and regression of liver fibrosis after long-term use of nucleos(t)ides analogues (NUCs) have been documented. The aim of the present investigation was to evaluate the usefulness of traditional sonography to detect hepatic and splenic changes during NUC therapy in chronic hepatitis B (CHB) patients. Methods A total of 181 CHB patients receiving NUC treatment were enrolled in this study. The study population was divided into three groups: 72 cirrhotic, 58 noncirrhotic CHB, and 51 nonreplicative hepatitis B virus carriers. All patients had blood chemistries taken and sonography at baseline and during the NUC treatment period. The changes in liver size, liver edge, spleen size, platelet count, and platelet count/spleen diameter (PC/SD) ratio were compared among the three groups of patients. Results CHB Patients with and without cirrhosis have improved clinical features during NUC therapy with lower aspartate aminotransferase, alanine aminotransferase, international normalized ratio, hepatitis B virus DNA, and spleen size and higher platelet, liver edge, liver size, and PC/SD ratio compared with the baseline data (p < 0.05). The differences in liver edge, liver size, spleen size, and PC/SD ratio are higher in the cirrhosis group than in the noncirrhotic group (p < 0.001). A decrease in spleen size exhibited a linear relationship with treatment duration (R2 = 0.905). Conclusions Traditional sonography is helpful to monitor changes in liver fibrosis of CHB patients under NUC therapy.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalJournal of Medical Ultrasound
Issue number3
Publication statusPublished - Sept 2017


  • antiviral nucleos(t)ides
  • cirrhosis
  • liver
  • sonography
  • spleen

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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