Long-term incidence of breast cancer by trial arm in one county of the Swedish Two-County Trial of mammographic screening

Amy Ming Fang Yen; Stephen W. Duffy; Tony Hsiu Hsi Chen; Li Sheng Chen; Sherry Yueh Hsia Chiu; Jean Ching Yuan Fann; Wendy Yi Ying Wu; Chiu Wen Su; Robert A. Smith; Lászlo Tabár

doi:10.1002/cncr.27580

Long-term incidence of breast cancer by trial arm in one county of the Swedish Two-County Trial of mammographic screening

Amy Ming Fang Yen, Stephen W. Duffy, Tony Hsiu Hsi Chen, Li Sheng Chen, Sherry Yueh Hsia Chiu, Jean Ching Yuan Fann, Wendy Yi Ying Wu, Chiu Wen Su, Robert A. Smith, Lászlo Tabár

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

BACKGROUND: This study estimated the excess incidence (overdiagnosis) of breast cancer associated with starting mammographic screening at an earlier age, by using data from the Dalarna County component of the Swedish Two-County Trial of breast cancer screening. METHODS: In Dalarna County, Sweden, 38,589 women aged 40 to 74 years were randomized to invitation to regular mammographic screening (active study population [ASP]) and 18,582 women to usual care (passive study population [PSP]). After 3 screening rounds (6-8 years after randomization), the PSP was invited to screening. The cumulative incidence of breast cancer was calculated in the ASP and PSP from randomization to 29 years later. In addition, cumulative incidence was calculated for invasive cancers, advanced invasive cancers (≥2 cm in maximum diameter or node-positive), and nonadvanced cancers (

Original language	English
Pages (from-to)	5728-5732
Number of pages	5
Journal	Cancer
Volume	118
Issue number	23
DOIs	https://doi.org/10.1002/cncr.27580
Publication status	Published - Dec 1 2012

Keywords

Sweden
breast neoplasms
mammography
overdiagnosis
randomized trials
screening

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cncr.27580

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title = "Long-term incidence of breast cancer by trial arm in one county of the Swedish Two-County Trial of mammographic screening",

abstract = "BACKGROUND: This study estimated the excess incidence (overdiagnosis) of breast cancer associated with starting mammographic screening at an earlier age, by using data from the Dalarna County component of the Swedish Two-County Trial of breast cancer screening. METHODS: In Dalarna County, Sweden, 38,589 women aged 40 to 74 years were randomized to invitation to regular mammographic screening (active study population [ASP]) and 18,582 women to usual care (passive study population [PSP]). After 3 screening rounds (6-8 years after randomization), the PSP was invited to screening. The cumulative incidence of breast cancer was calculated in the ASP and PSP from randomization to 29 years later. In addition, cumulative incidence was calculated for invasive cancers, advanced invasive cancers (≥2 cm in maximum diameter or node-positive), and nonadvanced cancers (",

keywords = "Sweden, breast neoplasms, mammography, overdiagnosis, randomized trials, screening",

author = "Yen, {Amy Ming Fang} and Duffy, {Stephen W.} and Chen, {Tony Hsiu Hsi} and Chen, {Li Sheng} and Chiu, {Sherry Yueh Hsia} and Fann, {Jean Ching Yuan} and Wu, {Wendy Yi Ying} and Su, {Chiu Wen} and Smith, {Robert A.} and L{\'a}szlo Tab{\'a}r",

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doi = "10.1002/cncr.27580",

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AU - Yen, Amy Ming Fang

AU - Duffy, Stephen W.

AU - Chen, Tony Hsiu Hsi

AU - Chen, Li Sheng

AU - Chiu, Sherry Yueh Hsia

AU - Fann, Jean Ching Yuan

AU - Wu, Wendy Yi Ying

AU - Su, Chiu Wen

AU - Smith, Robert A.

AU - Tabár, Lászlo

PY - 2012/12/1

Y1 - 2012/12/1

N2 - BACKGROUND: This study estimated the excess incidence (overdiagnosis) of breast cancer associated with starting mammographic screening at an earlier age, by using data from the Dalarna County component of the Swedish Two-County Trial of breast cancer screening. METHODS: In Dalarna County, Sweden, 38,589 women aged 40 to 74 years were randomized to invitation to regular mammographic screening (active study population [ASP]) and 18,582 women to usual care (passive study population [PSP]). After 3 screening rounds (6-8 years after randomization), the PSP was invited to screening. The cumulative incidence of breast cancer was calculated in the ASP and PSP from randomization to 29 years later. In addition, cumulative incidence was calculated for invasive cancers, advanced invasive cancers (≥2 cm in maximum diameter or node-positive), and nonadvanced cancers (

AB - BACKGROUND: This study estimated the excess incidence (overdiagnosis) of breast cancer associated with starting mammographic screening at an earlier age, by using data from the Dalarna County component of the Swedish Two-County Trial of breast cancer screening. METHODS: In Dalarna County, Sweden, 38,589 women aged 40 to 74 years were randomized to invitation to regular mammographic screening (active study population [ASP]) and 18,582 women to usual care (passive study population [PSP]). After 3 screening rounds (6-8 years after randomization), the PSP was invited to screening. The cumulative incidence of breast cancer was calculated in the ASP and PSP from randomization to 29 years later. In addition, cumulative incidence was calculated for invasive cancers, advanced invasive cancers (≥2 cm in maximum diameter or node-positive), and nonadvanced cancers (

KW - Sweden

KW - breast neoplasms

KW - mammography

KW - overdiagnosis

KW - randomized trials

KW - screening

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Long-term incidence of breast cancer by trial arm in one county of the Swedish Two-County Trial of mammographic screening

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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