TY - JOUR
T1 - Lithium interacts with cardiac remodeling
T2 - the fundamental value in the pharmacotherapy of bipolar disorder
AU - Chen, Pao Huan
AU - Chao, Tze Fan
AU - Kao, Yu Hsun
AU - Chen, Yi Jen
N1 - Funding Information:
This work was supported by research grants from Taipei Medical University, Wan Fang Hospital ( 105swf09 and 106swf02 ) and Ministry of Science and Technology of Taiwan ( MOST 104-2314-B-038-022 ).
Publisher Copyright:
© 2018
PY - 2019/1/10
Y1 - 2019/1/10
N2 - Patients with bipolar disorder (BD) have an increased risk of cardiovascular morbidity and mortality during the course of their illness. For over half a century, lithium has been the gold-standard medication used to treat the mood burdens of BD. In addition, lithium possesses several biological effects that may modulate cardiovascular risk in patients with BD. In this review, we update the current knowledge of cellular and molecular mechanisms underlying the possible cardiac actions of lithium. The mechanistic insights suggest that lithium at therapeutic levels potentially exerts cardioprotective effects on ischemic hearts by modulating structural and electrical remodeling. The possible cardioprotective actions of lithium may involve an extensive range of signaling pathways, including the Wnt/glycogen synthase kinase-3β phosphatidylinositol-3-kinase/protein kinase B, phosphoinositide/protein kinase C, and mitogen-activated protein kinase/extracellular signal-regulated kinase cascades. Accordingly, understanding the cardioprotective effects of lithium may lead to the development of a potential strategy for reducing cardiovascular morbidity in patients with BD.
AB - Patients with bipolar disorder (BD) have an increased risk of cardiovascular morbidity and mortality during the course of their illness. For over half a century, lithium has been the gold-standard medication used to treat the mood burdens of BD. In addition, lithium possesses several biological effects that may modulate cardiovascular risk in patients with BD. In this review, we update the current knowledge of cellular and molecular mechanisms underlying the possible cardiac actions of lithium. The mechanistic insights suggest that lithium at therapeutic levels potentially exerts cardioprotective effects on ischemic hearts by modulating structural and electrical remodeling. The possible cardioprotective actions of lithium may involve an extensive range of signaling pathways, including the Wnt/glycogen synthase kinase-3β phosphatidylinositol-3-kinase/protein kinase B, phosphoinositide/protein kinase C, and mitogen-activated protein kinase/extracellular signal-regulated kinase cascades. Accordingly, understanding the cardioprotective effects of lithium may lead to the development of a potential strategy for reducing cardiovascular morbidity in patients with BD.
KW - Bipolar disorder
KW - Cardioprotection
KW - Electrical remodeling
KW - Lithium
KW - Structural remodeling
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U2 - 10.1016/j.pnpbp.2018.07.018
DO - 10.1016/j.pnpbp.2018.07.018
M3 - Review article
AN - SCOPUS:85050672335
SN - 0278-5846
VL - 88
SP - 208
EP - 214
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
ER -