Abstract
Objective. To investigate the role of ligands for programmed cell death 1 (PD-L) in the pathogenesis of systemic lupus erythematosus (SLE). Methods. One hundred sixty-four patients with SLE and 160 healthy controls were enrolled in our study. The PD-L1 and PD-L2 polymorphisms were determined by polymerase chain reaction (PCR)/direct sequencing or restriction fragment length polymorphism (RFLP)-PCR. Results. The genotype distributions of PD-L2 47103 C/T polymorphisms in patients with SLE were significantly different from those of the controls (p = 0.003). The genotype frequency of PD-L2 47103 T/T, in comparison with 47103 C/C, was significantly increased in patients with SLE when compared with that of the controls (odds ratio 2.5,95% confidence interval 1.4-4.4, p = 0.001). A similar finding could also be found in the allele frequency of PD-L2 47103 T (SLE vs control, OR 1.7, 95% CI 1.3-2.4, p = 0.001). There were no significant differences in the genotype and allele frequencies of PD-L1 polymorphisms between the patients and controls. Conclusion. PD-L2 47103 T may be associated with susceptibility to SLE in Taiwan.
Original language | English |
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Pages (from-to) | 721-725 |
Number of pages | 5 |
Journal | Journal of Rheumatology |
Volume | 34 |
Issue number | 4 |
Publication status | Published - Apr 2007 |
Keywords
- Programmed cell death 1
- Programmed cell death 1 ligand
- Programmed cell death 2 ligand
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Immunology and Allergy
- Rheumatology
- Immunology