Licochalcone A induces endoplasmic reticulum stress-mediated apoptosis of endometrial cancer cells via upregulation of GRP78 expression

Min Hua Wu, Yi Hsien Hsieh, Chia Liang Lin, Tsung Ho Ying, Shih Min Hsia, Shu Ching Hsieh, Chien Hsing Lee, Chu Liang Lin

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Licochalcone A (LicA), a natural compound extracted from licorice root, has been shown to exert a variety of anticancer activities. Whether LicA has such effects on endometrial cancer (EMC) is unclear. This study aims to investigate the antitumor effects of LicA on EMC. Our results show that LicA significantly reduced the viability and induced apoptosis of EMC cells and EMC-7 cells from EMC patients. LicA was also found to induce endoplasmic reticulum (ER) stress, leading to increased expression of ER-related proteins (GRP78/PERK/IRE1α/CHOP) in EMC cell lines. Suppression of GRP78 expression in human EMC cells treated with LicA significantly attenuated the effects of LicA, resulting in reduced ER-stress mediated cell apoptosis and decreased expression of ER- and apoptosis-related proteins. Our findings demonstrate that LicA induces apoptosis in EMC cells through the GRP78-mediated ER-stress pathway, emphasizing the potential of LicA as an anticancer therapy for EMC.

Original languageEnglish
Pages (from-to)2961-2969
Number of pages9
JournalEnvironmental Toxicology
Volume39
Issue number5
DOIs
Publication statusPublished - May 2024

Keywords

  • apoptosis
  • endometrial cancer
  • endoplasmic reticulum
  • GRP78
  • licochalcone A

ASJC Scopus subject areas

  • Toxicology
  • Management, Monitoring, Policy and Law
  • Health, Toxicology and Mutagenesis

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