Leukocyte 8-hydroxy-2′-deoxyguanosine as an oxidative stress marker to predict cardiovascular events and death in chronic hemodialysis patients

Ching Fang Tang, Mei Yi Wu, Yau Huei Wei, Yang Ho, Ko Lin Kuo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Hemodialysis patients have a markedly increased risk of cardiovascular (CV) morbidity and mortality. Oxidative stress plays a pathogenic role in the progression of atherosclerosis and CV disease among chronic hemodialysis patients. The 8-hydroxy-2′-deoxyguanosine (8-OHdG) content in leukocyte deoxyribonucleic acid (DNA) has been shown as a sensitive and well-known biomarker of oxidant-induced DNA damage in chronic hemodialysis patients. Methods: We conducted a retrospective cohort study to investigate the association of leukocyte 8-OHdG and CV events and deaths in patients of chronic hemodialysis. In this study, 217 chronic hemodialysis patients were recruited from 2016 to 2021. The 8-OHdG content of leukocyte DNA was measured by a high-performance liquid chromatography electrochemical detection method. Study outcomes were CV events as well as CV and all-cause deaths. The patients were followed until May 2021. Results: The median follow-up period was 34.8 months. At the end of May 2021, 57 first CV events and 89 all-CV events occurred. Among the first and all CV events, 17 (29.8%) and 32 (36.0%) were fatal, respectively. Multivariate Cox regression analysis showed per 1/105dG increment in leukocyte 8-OHdG values increased risk of CV events (adjusted hazard ratio [aHR], 1.19; 95% CI, 1.10-1.41; p < 0.001), CV death (aHR, 1.27; 95% CI, 1.03-1.72; p = 0.034), and all-cause death (aHR, 1.11; 95% CI, 1.01-1.30; p = 0.038). Conclusion: This is the first study to demonstrate that oxidative stress assessed by 8-OHdG levels of leukocyte DNA predicted CV events as well as CV and all-cause deaths among chronic hemodialysis patients.

Original languageEnglish
Pages (from-to)911-916
Number of pages6
JournalJournal of the Chinese Medical Association
Volume86
Issue number10
DOIs
Publication statusPublished - Oct 1 2023

Keywords

  • Cardiovascular events
  • Death
  • Hemodialysis
  • Leukocyte 8-hydroxy-2′-deoxyguanosine
  • Oxidative stress

ASJC Scopus subject areas

  • General Medicine

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