Abstract
Methotrexate has been used as an important alternative therapy in the treatment of various rheumatic diseases. Life threatening marrow suppression in end-stage renal disease patients undergoing hemodialysis or continuous ambulatory peritoneal dialysis has been reported. A 33-year-old woman with systemic lupus erythematosus undergoing chronic peritoneal dialysis developed severe mucositis and pancytopenia after low-dose methotrexate treatment for arthritis. The leukocyte count recovered after methotrexate was withdrawn but a leukemoid blood picture developed during her recovery. No evidence of leukemia was found on bone marrow biopsy. The leukocyte count gradually returned to normal with conservative therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 513-517 |
| Number of pages | 5 |
| Journal | Chang Gung Medical Journal |
| Volume | 29 |
| Issue number | 5 |
| Publication status | Published - Sept 2006 |
| Externally published | Yes |
Keywords
- Continuous ambulatory peritoneal dialysis
- Leukemoid reaction
- Methotrexate
- Systemic lupus erythematosus
ASJC Scopus subject areas
- General Medicine