Lentiviral mediated gene delivery as an effective therapeutic approach for Parkinson disease

Violina Kakoty; Sarathlal K C; Sunil Kumar Dubey; Chih Hao Yang; Prashant Kesharwani; Rajeev Taliyan

doi:10.1016/j.neulet.2021.135769

Lentiviral mediated gene delivery as an effective therapeutic approach for Parkinson disease

Violina Kakoty, Sarathlal K C, Sunil Kumar Dubey, Chih Hao Yang, Prashant Kesharwani, Rajeev Taliyan

Research output: Contribution to journal › Review article › peer-review

9 Citations (Scopus)

Abstract

Continual strategies to devise a complete therapeutic cure for neurodegenerative conditions has been a challenge, majorly due to the presence of blood brain barrier. Lack of targeted delivery in order to minimize loss of dopamine (DA) neurones has been a major challenge to overcome anomalies in Parkinson Disease (PD). PD is a neuromotor degenerative disorder deteriorating motor coordination in affected individuals. Recent research has highlighted the use of lentiviral vectors (LVs) for selective delivery of neuroprotective substance for complete halt of disease progression in PD. LVs have the ability to infect both dividing and non-dividing cells along with non-encoding capability of viral protein that might elicit an immune response. This review will mainly focus on understanding the basic mechanism of action of LVs and its therapeutic aid in PD.

Original language	English
Article number	135769
Journal	Neuroscience Letters
Volume	750
DOIs	https://doi.org/10.1016/j.neulet.2021.135769
Publication status	Published - Apr 17 2021

Keywords

Blood brain barrier
Lentiviral vector
Parkinson disease

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2021.135769

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title = "Lentiviral mediated gene delivery as an effective therapeutic approach for Parkinson disease",

abstract = "Continual strategies to devise a complete therapeutic cure for neurodegenerative conditions has been a challenge, majorly due to the presence of blood brain barrier. Lack of targeted delivery in order to minimize loss of dopamine (DA) neurones has been a major challenge to overcome anomalies in Parkinson Disease (PD). PD is a neuromotor degenerative disorder deteriorating motor coordination in affected individuals. Recent research has highlighted the use of lentiviral vectors (LVs) for selective delivery of neuroprotective substance for complete halt of disease progression in PD. LVs have the ability to infect both dividing and non-dividing cells along with non-encoding capability of viral protein that might elicit an immune response. This review will mainly focus on understanding the basic mechanism of action of LVs and its therapeutic aid in PD.",

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note = "Funding Information: Authors are thankful to Birla Institute of Technology and Science-Pilani, Pilani campus Rajasthan, India, Taipei Medical University, Taipei, Taiwan and School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

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AU - Kakoty, Violina

AU - K C, Sarathlal

AU - Dubey, Sunil Kumar

AU - Yang, Chih Hao

AU - Kesharwani, Prashant

AU - Taliyan, Rajeev

N1 - Funding Information: Authors are thankful to Birla Institute of Technology and Science-Pilani, Pilani campus Rajasthan, India, Taipei Medical University, Taipei, Taiwan and School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. Publisher Copyright: © 2021 Elsevier B.V.

PY - 2021/4/17

Y1 - 2021/4/17

N2 - Continual strategies to devise a complete therapeutic cure for neurodegenerative conditions has been a challenge, majorly due to the presence of blood brain barrier. Lack of targeted delivery in order to minimize loss of dopamine (DA) neurones has been a major challenge to overcome anomalies in Parkinson Disease (PD). PD is a neuromotor degenerative disorder deteriorating motor coordination in affected individuals. Recent research has highlighted the use of lentiviral vectors (LVs) for selective delivery of neuroprotective substance for complete halt of disease progression in PD. LVs have the ability to infect both dividing and non-dividing cells along with non-encoding capability of viral protein that might elicit an immune response. This review will mainly focus on understanding the basic mechanism of action of LVs and its therapeutic aid in PD.

AB - Continual strategies to devise a complete therapeutic cure for neurodegenerative conditions has been a challenge, majorly due to the presence of blood brain barrier. Lack of targeted delivery in order to minimize loss of dopamine (DA) neurones has been a major challenge to overcome anomalies in Parkinson Disease (PD). PD is a neuromotor degenerative disorder deteriorating motor coordination in affected individuals. Recent research has highlighted the use of lentiviral vectors (LVs) for selective delivery of neuroprotective substance for complete halt of disease progression in PD. LVs have the ability to infect both dividing and non-dividing cells along with non-encoding capability of viral protein that might elicit an immune response. This review will mainly focus on understanding the basic mechanism of action of LVs and its therapeutic aid in PD.

KW - Blood brain barrier

KW - Lentiviral vector

KW - Parkinson disease

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Lentiviral mediated gene delivery as an effective therapeutic approach for Parkinson disease

Abstract

Keywords

ASJC Scopus subject areas

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