Left Ventricular Electromechanical Remodeling Detected by Acoustic Cardiography in Paroxysmal Atrial Fibrillation

Kuo Li Pan, Shih Lin Chang, Yenn Jiang Lin, Li Wei Lo, Yu Feng Hu, Fa Po Chung, Tze Fan Chao, Jo Nan Liao, Chin Yu Lin, Chung Hsing Lin, Abigail Louise D. Te, Shinya Yamada, Yao Ting Chang, Shih Ann Chen

Research output: Contribution to journalArticlepeer-review


This study aimed to investigate the electromechanical function detected by acoustic cardiography before and after radiofrequency ablation therapy (RFA) in paroxysmal AF (PAF) patients with preserved left ventricular ejection fraction (LVEF). Seventy-five symptomatic PAF patients and 69 patients without arrhythmia were enrolled. Thirty-seven PAF patients received RFA therapy. Acoustic cardiographic exam was performed to check S3 and S4 heart sound, electromechanical activation time (EMAT), LV systolic time percentage (LVST), and systolic dysfunction index (SDI) in all participants. Furthermore, 37 PAF patients also received follow-up acoustic cardiography postRFA. PAF had impaired electromechanical systolic function compared with health participants (%EMAT 14.69 ± 3.62 vs. 10.84 ± 2.62; %LVST 40.83 ± 5.14 vs. 36.70 ± 3.87; SDI 4.75 ± 1.61 vs. 3.26 ± 0.96 all p < 0.001). RFA can improve electromechanical systolic function. Improvement below 13.1% could predict the recurrent AF postcatheter ablation. Higher degree of improved electromechanical systolic function postRFA contribute to lower recurrence of AF. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)348-354
Number of pages7
JournalJournal of Cardiovascular Translational Research
Issue number2
Publication statusPublished - Apr 2021


  • Ablation
  • Acoustic cardiography
  • Electromechanical remodeling
  • Paroxysmal atrial fibrillation

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)


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