Larval Migratory Behavior of Long-term-maintained Toxocara canis Embryonated Eggs in Mice

Chia-Kwung Fan, Yun-Ho Lin, Chien Ching Hung, Kua-Eyre Su

Research output: Contribution to journalArticlepeer-review


Larval migratory behavior of Toxocara canis embryonated eggs that had been maintained in 2% formalin for 14 months at 4℃ was evaluated using a larval recovery study in mice at between 1 and 469 days post infection (DPI) . Three infected mice and 2 aged-matched uninfected control mice were sacrificed daily for acid-pepsin digestion of the liver and lungs (hepatopulmonary phase) as well as the musculature and brain (myotropic-neurotropic phase). Larval recovery from the hepatopulmonary phase reached a peak at 5 DPI, not at 2 DPI; thereafter, they began to migrate to the myotropic-neurotropic phase. Statistically, larval recoveries from the hepatopulmonary and myotropic-neurotropic phases respectively showed negative and positive correlations with time (r = - 0.688, P = 0.005; r = 0. 138, P = 0.327). Altogether, although there seemed to be a delay in the migration of 14-month-cultured T. canis larvae to the hepatopulmonary phase, most of them still exhibited the myotropic-neurotropic phase, especially in the brain.
Translated title of the contribution長期培養之犬蛔蟲受孕卵內幼蟲於小鼠的移行行為
Original languageEnglish
Pages (from-to)99-105
Number of pages7
Issue number2
Publication statusPublished - 2004


  • 犬蛔蟲
  • 幼蟲移行行為
  • 小鼠
  • Larval migratory behavior
  • Mice
  • Toxocara canis


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