Abstract
Background: The creation of a tissue microarray (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in a parallel fashion. This study applied TMA in order to analyse the topoisomerase II alpha status in breast cancer and to elucidate its relationship in breast cancer biology. Patients and Methods: Archived tissue specimens from 94 patients with primary invasive breast cancer were selected and the topoisomerase II alpha expression was analysed by TMA. Data concerning age, oestrogen receptor status, histological grading and TNM staging were also collected. Results: There were 20 patients (21.3%) with 1+ expression in topoisomerase II alpha, 33 patients (35.1%) with 2+ expression and 41 patients (43.6%) with 3+ expression. By multivariate analysis, oestrogen receptor status, histological grading and TNM staging were found to be significantly related to the overall five-year survival rate. Conclusion: Topoisomerase II alpha expression failed to demonstrate prognostic value in patients with breast cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 2459-2462 |
| Number of pages | 4 |
| Journal | Anticancer Research |
| Volume | 30 |
| Issue number | 6 |
| Publication status | Published - Jun 1 2010 |
| Externally published | Yes |
Keywords
- Breast cancer
- Topoisomerase II alpha
ASJC Scopus subject areas
- Oncology
- Cancer Research
