Lack of mutations of BCL6 and BCL10 genes in mucosa-associated lymphoid tissue lymphomas of the orbital adnexa

Po Min Chen; Jin Hwang Liu; I. Ting Yu; Shu Ching Kao; Yu Chen Lin; Hung Chiang; Frank Sheng Fan; Tzeon Jye Chiou; Wei Shu Wang; Chueh Chuan Yen

doi:10.1016/S0165-4608(00)00298-3

Lack of mutations of BCL6 and BCL10 genes in mucosa-associated lymphoid tissue lymphomas of the orbital adnexa

Po Min Chen, Jin Hwang Liu, I. Ting Yu, Shu Ching Kao, Yu Chen Lin, Hung Chiang, Frank Sheng Fan, Tzeon Jye Chiou, Wei Shu Wang, Chueh Chuan Yen

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Knowledge regarding the molecular pathogenesis and progression of mucosa-associated lymphoid tissue (MALT) lymphomas of ocular adnexa is limited. Eleven cases of ocular MALT lymphoma were analyzed by clonal rearrangement of antigen receptor genes using Southern blot hybridization. Polymerase chain reaction-single stranded conformational polymorphism analysis and DNA sequencing was utilized to analyze the mutations of BCL6 and BCL10 genes. Clonal rearrangement of immunoglobulin heavy genes was found in all 11 patients. No point mutation was found in BCL6 or BCL10 genes in any of the samples analyzed. We suggest that mutations of BCL6 and BCL10 genes are rare in low-grade MALT lymphoma of ocular adnexa and are unlikely to be involved in the pathogenesis of the disease. But the role of alterations of both BCL6 and BCL10 genes in the disease progression of low-grade MALT lymphoma require additional study. Copyright (C) 2000 Elsevier Science Inc.

Original language	English
Pages (from-to)	44-48
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	123
Issue number	1
DOIs	https://doi.org/10.1016/S0165-4608(00)00298-3
Publication status	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0165-4608(00)00298-3

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@article{3335f5717d554b5a8ec5a809f8dd69a3,

title = "Lack of mutations of BCL6 and BCL10 genes in mucosa-associated lymphoid tissue lymphomas of the orbital adnexa",

abstract = "Knowledge regarding the molecular pathogenesis and progression of mucosa-associated lymphoid tissue (MALT) lymphomas of ocular adnexa is limited. Eleven cases of ocular MALT lymphoma were analyzed by clonal rearrangement of antigen receptor genes using Southern blot hybridization. Polymerase chain reaction-single stranded conformational polymorphism analysis and DNA sequencing was utilized to analyze the mutations of BCL6 and BCL10 genes. Clonal rearrangement of immunoglobulin heavy genes was found in all 11 patients. No point mutation was found in BCL6 or BCL10 genes in any of the samples analyzed. We suggest that mutations of BCL6 and BCL10 genes are rare in low-grade MALT lymphoma of ocular adnexa and are unlikely to be involved in the pathogenesis of the disease. But the role of alterations of both BCL6 and BCL10 genes in the disease progression of low-grade MALT lymphoma require additional study. Copyright (C) 2000 Elsevier Science Inc.",

author = "Chen, {Po Min} and Liu, {Jin Hwang} and Yu, {I. Ting} and Kao, {Shu Ching} and Lin, {Yu Chen} and Hung Chiang and Fan, {Frank Sheng} and Chiou, {Tzeon Jye} and Wang, {Wei Shu} and Yen, {Chueh Chuan}",

note = "Funding Information: This work was supported by grants from the National Science Council of the Republic of China (NSC89-2314-B-075-033) and the Yen Tjing-ling Medical Foundation.",

year = "2000",

doi = "10.1016/S0165-4608(00)00298-3",

language = "English",

volume = "123",

pages = "44--48",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Lack of mutations of BCL6 and BCL10 genes in mucosa-associated lymphoid tissue lymphomas of the orbital adnexa

AU - Chen, Po Min

AU - Liu, Jin Hwang

AU - Yu, I. Ting

AU - Kao, Shu Ching

AU - Lin, Yu Chen

AU - Chiang, Hung

AU - Fan, Frank Sheng

AU - Chiou, Tzeon Jye

AU - Wang, Wei Shu

AU - Yen, Chueh Chuan

N1 - Funding Information: This work was supported by grants from the National Science Council of the Republic of China (NSC89-2314-B-075-033) and the Yen Tjing-ling Medical Foundation.

PY - 2000

Y1 - 2000

N2 - Knowledge regarding the molecular pathogenesis and progression of mucosa-associated lymphoid tissue (MALT) lymphomas of ocular adnexa is limited. Eleven cases of ocular MALT lymphoma were analyzed by clonal rearrangement of antigen receptor genes using Southern blot hybridization. Polymerase chain reaction-single stranded conformational polymorphism analysis and DNA sequencing was utilized to analyze the mutations of BCL6 and BCL10 genes. Clonal rearrangement of immunoglobulin heavy genes was found in all 11 patients. No point mutation was found in BCL6 or BCL10 genes in any of the samples analyzed. We suggest that mutations of BCL6 and BCL10 genes are rare in low-grade MALT lymphoma of ocular adnexa and are unlikely to be involved in the pathogenesis of the disease. But the role of alterations of both BCL6 and BCL10 genes in the disease progression of low-grade MALT lymphoma require additional study. Copyright (C) 2000 Elsevier Science Inc.

AB - Knowledge regarding the molecular pathogenesis and progression of mucosa-associated lymphoid tissue (MALT) lymphomas of ocular adnexa is limited. Eleven cases of ocular MALT lymphoma were analyzed by clonal rearrangement of antigen receptor genes using Southern blot hybridization. Polymerase chain reaction-single stranded conformational polymorphism analysis and DNA sequencing was utilized to analyze the mutations of BCL6 and BCL10 genes. Clonal rearrangement of immunoglobulin heavy genes was found in all 11 patients. No point mutation was found in BCL6 or BCL10 genes in any of the samples analyzed. We suggest that mutations of BCL6 and BCL10 genes are rare in low-grade MALT lymphoma of ocular adnexa and are unlikely to be involved in the pathogenesis of the disease. But the role of alterations of both BCL6 and BCL10 genes in the disease progression of low-grade MALT lymphoma require additional study. Copyright (C) 2000 Elsevier Science Inc.

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U2 - 10.1016/S0165-4608(00)00298-3

DO - 10.1016/S0165-4608(00)00298-3

M3 - Article

C2 - 11120333

AN - SCOPUS:0033663264

SN - 0165-4608

VL - 123

SP - 44

EP - 48

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

Lack of mutations of BCL6 and BCL10 genes in mucosa-associated lymphoid tissue lymphomas of the orbital adnexa

Abstract

ASJC Scopus subject areas

UN SDGs

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