TY - JOUR
T1 - Lack of association between plasma Dehydroepiandrosterone Sulfate (DHEA-S) levels and depression in hemodialysis patients
T2 - A cross-sectional study
AU - Hsu, Heng Jung
AU - Chen, Chih Ken
AU - Hsiao, Cheng Cheng
AU - Wu, I. Wen
AU - Sun, Chiao Yin
AU - Chou, Chia Chi
AU - Lee, Chin Chan
AU - Tsai, Chi Jen
AU - Wu, Mai Szu
PY - 2009/11
Y1 - 2009/11
N2 - Objective: Depression is common in hemodialysis patients. Reduced DHEA-S levels have been shown to be associated with depression in general population. Abnormalities in hormone production and metabolism are found in hemodialysis patients. However, the association between DHEA-S levels and depression in hemodialysis patients has not been established. Method: We conducted a cross-sectional study, in which 80 patients under regular hemodialysis were studied, and their serum DHEA-S levels were analyzed. Results: The prevalence of depression in our studied hemodialysis population is 37.5% (30/80). The DHEA-S level was 1138.1 ± 1216.9 ng/mL in male patients and 502.1 ± 389.4 ng/mL in female patients. The levels were not significantly different between patients with or without depression (910.8 ± 1127.1 ng/mL vs. 769.3 ± 848.3 ng/mL, P = 0.533). As compared to the non-depressed patients, the depressed patients were more likely to be male, with lower body mass index, consuming more alcohol, and with more co-morbidity. The prevalence of depression was not associated with age, educational background, smoking, duration of dialysis, hemoglobin, albumin, CRP, ferritin, and urea clearance (Kt/V and URR). The serum DHEA-S levels exhibited significant and independent associations with age, gender, diabetes mellitus, and the levels of serum albumin. Conclusion: The study suggested a lack of association between plasma DHEA-S levels and depression in hemodialysis patients.
AB - Objective: Depression is common in hemodialysis patients. Reduced DHEA-S levels have been shown to be associated with depression in general population. Abnormalities in hormone production and metabolism are found in hemodialysis patients. However, the association between DHEA-S levels and depression in hemodialysis patients has not been established. Method: We conducted a cross-sectional study, in which 80 patients under regular hemodialysis were studied, and their serum DHEA-S levels were analyzed. Results: The prevalence of depression in our studied hemodialysis population is 37.5% (30/80). The DHEA-S level was 1138.1 ± 1216.9 ng/mL in male patients and 502.1 ± 389.4 ng/mL in female patients. The levels were not significantly different between patients with or without depression (910.8 ± 1127.1 ng/mL vs. 769.3 ± 848.3 ng/mL, P = 0.533). As compared to the non-depressed patients, the depressed patients were more likely to be male, with lower body mass index, consuming more alcohol, and with more co-morbidity. The prevalence of depression was not associated with age, educational background, smoking, duration of dialysis, hemoglobin, albumin, CRP, ferritin, and urea clearance (Kt/V and URR). The serum DHEA-S levels exhibited significant and independent associations with age, gender, diabetes mellitus, and the levels of serum albumin. Conclusion: The study suggested a lack of association between plasma DHEA-S levels and depression in hemodialysis patients.
KW - DHEA-S
KW - Depression
KW - End-stage renal disease
KW - Hemodialysis
KW - Steroid hormone
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U2 - 10.1016/j.exger.2009.08.009
DO - 10.1016/j.exger.2009.08.009
M3 - Article
C2 - 19732820
AN - SCOPUS:70350375283
SN - 0531-5565
VL - 44
SP - 733
EP - 739
JO - Experimental Gerontology
JF - Experimental Gerontology
IS - 11
ER -
